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Progressive resistance training and cancer testis (PROTRACT) - efficacy of resistance training on muscle function, morphology and inflammatory profile in testicular cancer patients undergoing chemotherapy: design of a randomized controlled trial

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@article{1d8e3901330f4f1eb2425d4771dae68c,
title = "Progressive resistance training and cancer testis (PROTRACT) - efficacy of resistance training on muscle function, morphology and inflammatory profile in testicular cancer patients undergoing chemotherapy: design of a randomized controlled trial",
abstract = "Standard treatment for patients with disseminated germ cell tumors is combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This treatment is highly effective, but the majority of patients experience severe adverse effects during treatment and are at risk of developing considerable long-term morbidity, including second malignant neoplasms, cardiovascular disease, and pulmonary toxicity. One neglected side effect is the significant muscular fatigue mentioned by many patients with testicular cancer both during and after treatment. Very limited information exists concerning the patho-physiological effects of antineoplastic agents on skeletal muscle. The primary aim of this study is to investigate the effects of BEP-treatment on the skeletal musculature in testicular cancer patients, and to examine whether the expected treatment-induced muscular deterioration can be attenuated or even reversed by high intensity progressive resistance training (HIPRT).",
author = "Christensen, {Jesper F} and Andersen, {Jesper L} and Lis Adamsen and Birgitte Lindegaard and Mackey, {Abigail L} and Nielsen, {Rie H} and Mikael R{\o}rth and Gedske Daugaard",
year = "2011",
month = "8",
day = "1",
doi = "10.1186/1471-2407-11-326",
language = "English",
volume = "11",
pages = "326",
journal = "B M C Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd",

}

RIS

TY - JOUR

T1 - Progressive resistance training and cancer testis (PROTRACT) - efficacy of resistance training on muscle function, morphology and inflammatory profile in testicular cancer patients undergoing chemotherapy: design of a randomized controlled trial

AU - Christensen, Jesper F

AU - Andersen, Jesper L

AU - Adamsen, Lis

AU - Lindegaard, Birgitte

AU - Mackey, Abigail L

AU - Nielsen, Rie H

AU - Rørth, Mikael

AU - Daugaard, Gedske

PY - 2011/8/1

Y1 - 2011/8/1

N2 - Standard treatment for patients with disseminated germ cell tumors is combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This treatment is highly effective, but the majority of patients experience severe adverse effects during treatment and are at risk of developing considerable long-term morbidity, including second malignant neoplasms, cardiovascular disease, and pulmonary toxicity. One neglected side effect is the significant muscular fatigue mentioned by many patients with testicular cancer both during and after treatment. Very limited information exists concerning the patho-physiological effects of antineoplastic agents on skeletal muscle. The primary aim of this study is to investigate the effects of BEP-treatment on the skeletal musculature in testicular cancer patients, and to examine whether the expected treatment-induced muscular deterioration can be attenuated or even reversed by high intensity progressive resistance training (HIPRT).

AB - Standard treatment for patients with disseminated germ cell tumors is combination chemotherapy with bleomycin, etoposide and cisplatin (BEP). This treatment is highly effective, but the majority of patients experience severe adverse effects during treatment and are at risk of developing considerable long-term morbidity, including second malignant neoplasms, cardiovascular disease, and pulmonary toxicity. One neglected side effect is the significant muscular fatigue mentioned by many patients with testicular cancer both during and after treatment. Very limited information exists concerning the patho-physiological effects of antineoplastic agents on skeletal muscle. The primary aim of this study is to investigate the effects of BEP-treatment on the skeletal musculature in testicular cancer patients, and to examine whether the expected treatment-induced muscular deterioration can be attenuated or even reversed by high intensity progressive resistance training (HIPRT).

U2 - 10.1186/1471-2407-11-326

DO - 10.1186/1471-2407-11-326

M3 - Journal article

VL - 11

SP - 326

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

ER -

ID: 33270075