Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit

C Eggers, A Schmidt, J Hagenah, N Brüggemann, J C Klein, V Tadic, L Kertelge, M Kasten, F Binkofski, H Siebner, B Neumaier, G R Fink, R Hilker, C Klein

56 Citations (Scopus)

Abstract

While homozygous mutations in the PINK1 gene cause recessively inherited early-onset Parkinson disease (PD), heterozygous mutations have been suggested as a susceptibility factor.
Original languageEnglish
JournalNeurology
Volume74
Issue number22
Pages (from-to)1798-805
Number of pages7
DOIs
Publication statusPublished - 2010

Keywords

  • Adult
  • Brain Mapping
  • Corpus Striatum
  • Dopamine
  • Female
  • Follow-Up Studies
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Parkinson Disease
  • Positron-Emission Tomography
  • Protein Kinases
  • Severity of Illness Index
  • Statistics, Nonparametric

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