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Prognostic value of 18F-fludeoxyglucose uptake in 287 patients with head and neck squamous cell carcinoma

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@article{05449e3f7fcb43e7bb2e273c934b4c20,
title = "Prognostic value of 18F-fludeoxyglucose uptake in 287 patients with head and neck squamous cell carcinoma",
abstract = "BACKGROUND: The prognostic value of 18F-Fludeoxyglucose (FDG) uptake could be due to its association with already known clinical risk factors.METHODS: Correlation between FDG uptake metrics and other known risk factors from 287 patients were analyzed. Time to any failure was analyzed using Cox proportional hazards model stratified by tumor subsite. The resulting multivariate prognostic model was used to generate a table of 2-year freedom from failure estimates with confidence intervals (CIs).RESULTS: Increasing values of standardized uptake value maximum (SUVmax) correlated with other known risk factors. The reduced Cox model included SUVmax (hazard ratio [HR] = 1.34), cisplatin (HR = 0.37), smoking status (HR = 1.49), and gross target volume (GTV; HR = 1.74) as significant prognostic factors. Including SUVmax in the model changed the 2-year failure estimate by more than 10% for a quarter of the patients (23%).CONCLUSION: FDG uptake retains statistical significance in a multivariate analysis and has clinically relevant prognostic impact. We developed a prognostic model for risk stratification of patients in a clinical setting.",
author = "Rasmussen, {Jacob H} and Vogelius, {Ivan R} and Fischer, {Barbara M} and Jeppe Friborg and Aznar, {Marianne C} and Persson, {Gitte Bj{\o}rnsen Fredberg} and Katrin H{\aa}kansson and Kristensen, {Claus A} and Bentzen, {S{\o}ren M} and Lena Specht",
note = "{\textcopyright} 2014 Wiley Periodicals, Inc.",
year = "2015",
month = sep,
doi = "10.1002/hed.23745",
language = "English",
volume = "37",
pages = "1274--81",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "9",

}

RIS

TY - JOUR

T1 - Prognostic value of 18F-fludeoxyglucose uptake in 287 patients with head and neck squamous cell carcinoma

AU - Rasmussen, Jacob H

AU - Vogelius, Ivan R

AU - Fischer, Barbara M

AU - Friborg, Jeppe

AU - Aznar, Marianne C

AU - Persson, Gitte Bjørnsen Fredberg

AU - Håkansson, Katrin

AU - Kristensen, Claus A

AU - Bentzen, Søren M

AU - Specht, Lena

N1 - © 2014 Wiley Periodicals, Inc.

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: The prognostic value of 18F-Fludeoxyglucose (FDG) uptake could be due to its association with already known clinical risk factors.METHODS: Correlation between FDG uptake metrics and other known risk factors from 287 patients were analyzed. Time to any failure was analyzed using Cox proportional hazards model stratified by tumor subsite. The resulting multivariate prognostic model was used to generate a table of 2-year freedom from failure estimates with confidence intervals (CIs).RESULTS: Increasing values of standardized uptake value maximum (SUVmax) correlated with other known risk factors. The reduced Cox model included SUVmax (hazard ratio [HR] = 1.34), cisplatin (HR = 0.37), smoking status (HR = 1.49), and gross target volume (GTV; HR = 1.74) as significant prognostic factors. Including SUVmax in the model changed the 2-year failure estimate by more than 10% for a quarter of the patients (23%).CONCLUSION: FDG uptake retains statistical significance in a multivariate analysis and has clinically relevant prognostic impact. We developed a prognostic model for risk stratification of patients in a clinical setting.

AB - BACKGROUND: The prognostic value of 18F-Fludeoxyglucose (FDG) uptake could be due to its association with already known clinical risk factors.METHODS: Correlation between FDG uptake metrics and other known risk factors from 287 patients were analyzed. Time to any failure was analyzed using Cox proportional hazards model stratified by tumor subsite. The resulting multivariate prognostic model was used to generate a table of 2-year freedom from failure estimates with confidence intervals (CIs).RESULTS: Increasing values of standardized uptake value maximum (SUVmax) correlated with other known risk factors. The reduced Cox model included SUVmax (hazard ratio [HR] = 1.34), cisplatin (HR = 0.37), smoking status (HR = 1.49), and gross target volume (GTV; HR = 1.74) as significant prognostic factors. Including SUVmax in the model changed the 2-year failure estimate by more than 10% for a quarter of the patients (23%).CONCLUSION: FDG uptake retains statistical significance in a multivariate analysis and has clinically relevant prognostic impact. We developed a prognostic model for risk stratification of patients in a clinical setting.

U2 - 10.1002/hed.23745

DO - 10.1002/hed.23745

M3 - Journal article

C2 - 24801812

VL - 37

SP - 1274

EP - 1281

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 9

ER -

ID: 45941451