Prognostic impacts of glucocorticoid treatment in patients with polymyalgia rheumatica and giant cell arteritis

Amir Emamifar; Torkell Ellingsen; Anne Pernille Hermann; Søren Hess; Oke Gerke; Ziba Ahangarani Farahani; Per Syrak Hansen; Inger Marie Jensen Hansen; Peter Thye-Rønn

doi:10.1038/s41598-021-85857-4

Prognostic impacts of glucocorticoid treatment in patients with polymyalgia rheumatica and giant cell arteritis

Amir Emamifar, Torkell Ellingsen, Anne Pernille Hermann, Søren Hess, Oke Gerke, Ziba Ahangarani Farahani, Per Syrak Hansen, Inger Marie Jensen Hansen, Peter Thye-Rønn

10 Citations (Scopus)

Abstract

Identifying comorbidities in polymyalgia rheumatica/giant cell arteritis (PMR/GCA) is crucial for patients' outcomes. The present study aimed to evaluate the impact of the inflammatory process and glucocorticoid treatment on aortic arterial stiffness and body composition in PMR/GCA. 77 patients with newly diagnosed PMR/GCA were treated with oral glucocorticoids and followed for 40 weeks. Aortic pulse wave velocity (PWV) was measured at baseline and during the follow-up period and compared to the results of temporal artery biopsy (TAB) and 18F-FDG PET/CT. Body composition was assessed by total body DXA at baseline and the end of the study. Of 77 patients (49 (63.6%) female, mean of age: (71.8 ± 8.0)), 64 (83.1%) had pure PMR, 10 (13.0%) concomitant PMR and GCA, and 3 (3.9%) pure GCA. Compared to baseline values, aortic PWV was initially decreased at week 16 (p = 0.010) and remained lower than baseline at week 28 (p = 0.002) and week 40 (p

Original language	English
Article number	6220
Journal	Scientific Reports
Volume	11
Issue number	1
Pages (from-to)	6220
ISSN	2045-2322
DOIs	https://doi.org/10.1038/s41598-021-85857-4
Publication status	Published - Dec 2021
Externally published	Yes

Keywords

Adipose Tissue, White/diagnostic imaging
Age Factors
Aged
Aged, 80 and over
Aorta/drug effects
Biopsy
Blood Pressure/drug effects
Body Composition/drug effects
Bone Density/drug effects
C-Reactive Protein/metabolism
Female
Fluorodeoxyglucose F18/metabolism
Giant Cell Arteritis/blood
Glucocorticoids/therapeutic use
Humans
Longitudinal Studies
Male
Polymyalgia Rheumatica/blood
Positron Emission Tomography Computed Tomography
Prednisolone/therapeutic use
Prognosis
Pulse Wave Analysis
Sex Factors
Temporal Arteries/drug effects
Vascular Stiffness/drug effects

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10.1038/s41598-021-85857-4

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title = "Prognostic impacts of glucocorticoid treatment in patients with polymyalgia rheumatica and giant cell arteritis",

abstract = "Identifying comorbidities in polymyalgia rheumatica/giant cell arteritis (PMR/GCA) is crucial for patients' outcomes. The present study aimed to evaluate the impact of the inflammatory process and glucocorticoid treatment on aortic arterial stiffness and body composition in PMR/GCA. 77 patients with newly diagnosed PMR/GCA were treated with oral glucocorticoids and followed for 40 weeks. Aortic pulse wave velocity (PWV) was measured at baseline and during the follow-up period and compared to the results of temporal artery biopsy (TAB) and 18F-FDG PET/CT. Body composition was assessed by total body DXA at baseline and the end of the study. Of 77 patients (49 (63.6\%) female, mean of age: (71.8 ± 8.0)), 64 (83.1\%) had pure PMR, 10 (13.0\%) concomitant PMR and GCA, and 3 (3.9\%) pure GCA. Compared to baseline values, aortic PWV was initially decreased at week 16 (p = 0.010) and remained lower than baseline at week 28 (p = 0.002) and week 40 (p ",

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author = "Amir Emamifar and Torkell Ellingsen and Hermann, \{Anne Pernille\} and S{\o}ren Hess and Oke Gerke and \{Ahangarani Farahani\}, Ziba and \{Syrak Hansen\}, Per and \{Jensen Hansen\}, \{Inger Marie\} and Peter Thye-R{\o}nn",

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T1 - Prognostic impacts of glucocorticoid treatment in patients with polymyalgia rheumatica and giant cell arteritis

AU - Emamifar, Amir

AU - Ellingsen, Torkell

AU - Hermann, Anne Pernille

AU - Hess, Søren

AU - Gerke, Oke

AU - Ahangarani Farahani, Ziba

AU - Syrak Hansen, Per

AU - Jensen Hansen, Inger Marie

AU - Thye-Rønn, Peter

N1 - M1 - 6220

PY - 2021/12

Y1 - 2021/12

N2 - Identifying comorbidities in polymyalgia rheumatica/giant cell arteritis (PMR/GCA) is crucial for patients' outcomes. The present study aimed to evaluate the impact of the inflammatory process and glucocorticoid treatment on aortic arterial stiffness and body composition in PMR/GCA. 77 patients with newly diagnosed PMR/GCA were treated with oral glucocorticoids and followed for 40 weeks. Aortic pulse wave velocity (PWV) was measured at baseline and during the follow-up period and compared to the results of temporal artery biopsy (TAB) and 18F-FDG PET/CT. Body composition was assessed by total body DXA at baseline and the end of the study. Of 77 patients (49 (63.6%) female, mean of age: (71.8 ± 8.0)), 64 (83.1%) had pure PMR, 10 (13.0%) concomitant PMR and GCA, and 3 (3.9%) pure GCA. Compared to baseline values, aortic PWV was initially decreased at week 16 (p = 0.010) and remained lower than baseline at week 28 (p = 0.002) and week 40 (p

AB - Identifying comorbidities in polymyalgia rheumatica/giant cell arteritis (PMR/GCA) is crucial for patients' outcomes. The present study aimed to evaluate the impact of the inflammatory process and glucocorticoid treatment on aortic arterial stiffness and body composition in PMR/GCA. 77 patients with newly diagnosed PMR/GCA were treated with oral glucocorticoids and followed for 40 weeks. Aortic pulse wave velocity (PWV) was measured at baseline and during the follow-up period and compared to the results of temporal artery biopsy (TAB) and 18F-FDG PET/CT. Body composition was assessed by total body DXA at baseline and the end of the study. Of 77 patients (49 (63.6%) female, mean of age: (71.8 ± 8.0)), 64 (83.1%) had pure PMR, 10 (13.0%) concomitant PMR and GCA, and 3 (3.9%) pure GCA. Compared to baseline values, aortic PWV was initially decreased at week 16 (p = 0.010) and remained lower than baseline at week 28 (p = 0.002) and week 40 (p

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KW - Aged

KW - Aged, 80 and over

KW - Aorta/drug effects

KW - Biopsy

KW - Blood Pressure/drug effects

KW - Body Composition/drug effects

KW - Bone Density/drug effects

KW - C-Reactive Protein/metabolism

KW - Female

KW - Fluorodeoxyglucose F18/metabolism

KW - Giant Cell Arteritis/blood

KW - Glucocorticoids/therapeutic use

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Polymyalgia Rheumatica/blood

KW - Positron Emission Tomography Computed Tomography

KW - Prednisolone/therapeutic use

KW - Prognosis

KW - Pulse Wave Analysis

KW - Sex Factors

KW - Temporal Arteries/drug effects

KW - Vascular Stiffness/drug effects

UR - https://www.scopus.com/pages/publications/85102761645

U2 - 10.1038/s41598-021-85857-4

DO - 10.1038/s41598-021-85857-4

M3 - Journal article

C2 - 33737697

SN - 2045-2322

VL - 11

SP - 6220

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 6220

ER -

Prognostic impacts of glucocorticoid treatment in patients with polymyalgia rheumatica and giant cell arteritis

Abstract

Keywords

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