Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Simon Østergaard; Lars Munksgaard; Troels Hammer; Mette Ø Pedersen; Torsten H Nielsen; Lise Mette R Gjerdrum

doi:10.1111/bjh.19809

Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Simon Østergaard^*, Lars Munksgaard, Troels Hammer, Mette Ø Pedersen, Torsten H Nielsen, Lise Mette R Gjerdrum

^*Corresponding author for this work

Department of Haematology

Abstract

The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

Original language	English
Journal	British Journal of Haematology
Volume	205
Issue number	6
Pages (from-to)	2282-2286
Number of pages	5
ISSN	0007-1048
DOIs	https://doi.org/10.1111/bjh.19809
Publication status	Published - Dec 2024

Keywords

Adult
Aged
Aged, 80 and over
Female
Humans
Lymph Nodes/pathology
Male
Middle Aged
Prognosis
Waldenstrom Macroglobulinemia/mortality
extra-medullary disease
Waldenström's macroglobulinaemia
prognosis
non-Hodgkin's lymphoma
histological transformation

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10.1111/bjh.19809

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title = "Prognostic impact of nodal involvement in Waldenstr{\"o}m macroglobulinaemia",

abstract = "The clinical and prognostic implications of nodal involvement (NI) in Waldenstr{\"o}m macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.",

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author = "Simon {\O}stergaard and Lars Munksgaard and Troels Hammer and Pedersen, {Mette {\O}} and Nielsen, {Torsten H} and Gjerdrum, {Lise Mette R}",

note = "{\textcopyright} 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2024",

month = dec,

doi = "10.1111/bjh.19809",

language = "English",

volume = "205",

pages = "2282--2286",

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AU - Østergaard, Simon

AU - Munksgaard, Lars

AU - Hammer, Troels

AU - Pedersen, Mette Ø

AU - Nielsen, Torsten H

AU - Gjerdrum, Lise Mette R

PY - 2024/12

Y1 - 2024/12

N2 - The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

AB - The clinical and prognostic implications of nodal involvement (NI) in Waldenström macroglobulinaemia (WM) are largely unknown. In this study, we explored the impact of NI on clinical presentation and outcome in a population-based cohort of 469 patients with WM, consecutively diagnosed between 2000 and 2022. NI was detected in 34% of patients and was associated with symptomatic disease, adverse prognostic factors, an increased risk of transformation, and lymphoma-related death. Our findings indicate that NI is of prognostic significance in WM, suggesting a need for enhanced surveillance in these patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Humans

KW - Lymph Nodes/pathology

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Waldenstrom Macroglobulinemia/mortality

KW - extra-medullary disease

KW - Waldenström's macroglobulinaemia

KW - prognosis

KW - non-Hodgkin's lymphoma

KW - histological transformation

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U2 - 10.1111/bjh.19809

DO - 10.1111/bjh.19809

M3 - Journal article

C2 - 39350605

SN - 0007-1048

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SP - 2282

EP - 2286

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Prognostic impact of nodal involvement in Waldenström macroglobulinaemia

Abstract

Keywords

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