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Prognosis of Allogeneic Haematopoietic Stem Cell Recipients Admitted to the Intensive Care Unit: A Retrospective, Single-Centre Study

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BACKGROUND: Allogeneic haematopoietic stem cell transplantation (HSCT) is a procedure with inherent complications and intensive care may be necessary. We evaluated the short- and long-term outcomes of the HSCT recipients requiring admission to the intensive care unit (ICU).

METHODS: We retrospectively examined the outcome of 54 adult haematological HSCT recipients admitted to the ICU at the University Hospital Rigshospitalet between January 2007 and March 2012.

RESULTS: The overall in-ICU, in-hospital, 6-month and 1-year mortality rates were 46.3, 75.9, 79.6 and 86.5%, respectively. Mechanical ventilation had a statistically significant effect on in-ICU (p = 0.02), 6-month (p = 0.049) and 1-year (p = 0.014) mortality. Renal replacement therapy also had a statistically significant effect on in-hospital (p = 0.038) and 6-month (p = 0.026) mortality. Short ICU admissions, i.e. <10 days, had a statistically significant positive effect on in-hospital, 6-month and 1-year mortality (all p < 0.001). The SAPS II, APACHE II and SOFA scoring systems grossly underestimated the actual in-hospital mortality observed for these patients.

CONCLUSION: The poor prognosis of critically ill HSCT recipients admitted to the ICU was confirmed in our study. Mechanical ventilation, renal replacement therapy and an ICU admission of ≥10 days were each risk factors for mortality in the first year after ICU admission.

Original languageEnglish
JournalActa Haematologica
Volume135
Issue number2
Pages (from-to)72-8
Number of pages7
ISSN0001-5792
DOIs
Publication statusPublished - 2016

    Research areas

  • Adolescent, Adult, Aged, Critical Illness, Female, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Hematopoietic Stem Cells, Hospital Mortality, Hospitals, University, Humans, Intensive Care Units, Lymphoma, Male, Middle Aged, Prognosis, Renal Replacement Therapy, Retrospective Studies, Transplantation, Homologous, Young Adult, Journal Article

ID: 49630947