Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets

Rajesh Kumar; Albert Salehi; Jens F Rehfeld; Peter Höglund; Erik Lindström; Rolf Håkanson

doi:10.1016/j.regpep.2010.06.005

Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets

Rajesh Kumar, Albert Salehi, Jens F Rehfeld, Peter Höglund, Erik Lindström, Rolf Håkanson

Clinical Chemistry, Department of

36 Citations (Scopus)

Abstract

Proghrelin, produced by the ghrelin (A-like) cells of the gastric mucosa, gives rise to cleavage products, including desacyl ghrelin, acyl ghrelin and obestatin. The products are thought to be secreted concomitantly. In an earlier study we found acyl ghrelin and obestatin, but not desacyl ghrelin, to suppress the release of hormones from isolated islets of mouse and rat pancreas.

Original language	English
Journal	Regulatory Peptides
Volume	164
Issue number	2-3
Pages (from-to)	65-70
Number of pages	6
ISSN	0167-0115
DOIs	https://doi.org/10.1016/j.regpep.2010.06.005
Publication status	Published - 24 Sep 2010

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Kumar, R., Salehi, A., Rehfeld, J. F., Höglund, P., Lindström, E., & Håkanson, R. (2010). Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets. Regulatory Peptides, 164(2-3), 65-70. https://doi.org/10.1016/j.regpep.2010.06.005

Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets. / Kumar, Rajesh; Salehi, Albert; Rehfeld, Jens F et al.

In: Regulatory Peptides, Vol. 164, No. 2-3, 24.09.2010, p. 65-70.

Research output: Contribution to journal › Journal article › Research › peer-review

Kumar, R, Salehi, A, Rehfeld, JF, Höglund, P, Lindström, E & Håkanson, R 2010, 'Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets', Regulatory Peptides, vol. 164, no. 2-3, pp. 65-70. https://doi.org/10.1016/j.regpep.2010.06.005

Kumar R, Salehi A, Rehfeld JF, Höglund P, Lindström E, Håkanson R. Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets. Regulatory Peptides. 2010 Sep 24;164(2-3):65-70. https://doi.org/10.1016/j.regpep.2010.06.005

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