Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Glucagon Clearance is Preserved in Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Differential DNA Methylation and Expression of miRNAs in Adipose Tissue From Twin Pairs Discordant for Type 2 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The low-expression variant of FABP4 is associated with cardiovascular disease in type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The power of genetic diversity in genome-wide association studies of lipids

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Combinatorial, additive and dose-dependent drug–microbiome associations

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Airway hyperresponsiveness to inhaled mannitol identifies a cluster of non-eosinophilic asthma patients with high symptom burden

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Once-weekly subcutaneous semaglutide treatment for persons with type 2 diabetes: Real-world data from a diabetes out-patient clinic

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Andrea Tura
  • Eleonora Grespan
  • Christian S. Göbl
  • Robert W. Koivula
  • Paul W. Franks
  • Ewan R. Pearson
  • Mark Walker
  • Ian M. Forgie
  • Giuseppe N. Giordano
  • Imre Pavo
  • Hartmut Ruetten
  • Emmanouil T. Dermitzakis
  • Mark I. McCarthy
  • Oluf Pedersen
  • Jochen M. Schwenk
  • Jerzy Adamski
  • Federico De Masi
  • Konstantinos D. Tsirigos
  • Søren Brunak
  • Ana Viñuela
  • Anubha Mahajan
  • Timothy J. McDonald
  • Tarja Kokkola
  • Jagadish Vangipurapu
  • Henna Cederberg
  • Markku Laakso
  • Femke Rutters
  • Petra J.M. Elders
  • Anitra D.M. Koopman
  • Joline W. Beulens
  • Martin Ridderstråle
  • Tue H. Hansen
  • Kristine H. Allin
  • Torben Hansen
  • Henrik Vestergaard
  • Andrea Mari
  • IMI-DIRECT consortium
View graph of relations

Differences in glucose metabolism among categories of prediabetes have not been systematically investigated. In this longitudinal study, participants (N = 2,111) underwent a 2-h 75-g oral glucose tolerance test (OGTT) at baseline and 48 months. HbA1c was also measured. We classified participants as having isolated prediabetes defect (impaired fasting glucose [IFG], impaired glucose tolerance [IGT], or HbA1c indicative of prediabetes [IA1c]), two defects (IFG+IGT, IFG+IA1c, or IGT+IA1c), or all defects (IFG+IGT+IA1c). β-Cell function (BCF) and insulin sensitivity were assessed from OGTT. At baseline, in pooling of participants with isolated defects, they showed impairment in both BCF and insulin sensitivity compared with healthy control subjects. Pooled groups with two or three defects showed progressive further deterioration. Among groups with isolated defect, those with IGT showed lower insulin sensitivity, insulin secretion at reference glucose (ISRr), and insulin secretion potentiation (P < 0.002). Conversely, those with IA1c showed higher insulin sensitivity and ISRr (P < 0.0001). Among groups with two defects, we similarly found differences in both BCF and insulin sensitivity. At 48 months, we found higher type 2 diabetes incidence for progressively increasing number of prediabetes defects (odds ratio >2, P < 0.008). In conclusion, the prediabetes groups showed differences in type/degree of glucometabolic impairment. Compared with the pooled group with isolated defects, those with double or triple defect showed progressive differences in diabetes incidence.

Original languageEnglish
JournalDiabetes
Volume70
Issue number9
Pages (from-to)2092-2106
Number of pages15
ISSN0012-1797
DOIs
Publication statusPublished - 1 Sep 2021

Bibliographical note

Publisher Copyright:
© 2021 by the American Diabetes Association.

    Research areas

  • Adult, Aged, Blood Glucose, Fasting/blood, Female, Glucose Intolerance/metabolism, Glucose Tolerance Test, Glucose/metabolism, Glycated Hemoglobin A/analysis, Humans, Insulin Resistance/physiology, Insulin Secretion, Male, Middle Aged, Phenotype, Prediabetic State/metabolism

ID: 68816395