Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

Jan Claassen; Yama Akbari; Sheila Alexander; Mary Kay Bader; Kathleen Bell; Thomas P Bleck; Melanie Boly; Jeremy Brown; Sherry H-Y Chou; Michael N Diringer; Brian L Edlow; Brandon Foreman; Joseph T Giacino; Olivia Gosseries; Theresa Green; David M Greer; Daniel F Hanley; Jed A Hartings; Raimund Helbok; J Claude Hemphill; H E Hinson; Karen Hirsch; Theresa Human; Michael L James; Nerissa Ko; Daniel Kondziella; Sarah Livesay; Lori K Madden; Shraddha Mainali; Stephan A Mayer; Victoria McCredie; Molly M McNett; Geert Meyfroidt; Martin M Monti; Susanne Muehlschlegel; Santosh Murthy; Paul Nyquist; DaiWai M Olson; J Javier Provencio; Eric Rosenthal; Gisele Sampaio Silva; Simone Sarasso; Nicholas D Schiff; Tarek Sharshar; Lori Shutter; Robert D Stevens; Paul Vespa; Walter Videtta; Amy Wagner; Wendy Ziai; Curing Coma Campaign

doi:10.1007/s12028-021-01260-x

Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

Jan Claassen, Yama Akbari, Sheila Alexander, Mary Kay Bader, Kathleen Bell, Thomas P Bleck, Melanie Boly, Jeremy Brown, Sherry H-Y Chou, Michael N Diringer, Brian L Edlow, Brandon Foreman, Joseph T Giacino, Olivia Gosseries, Theresa Green, David M Greer, Daniel F Hanley, Jed A Hartings, Raimund Helbok, J Claude HemphillH E Hinson, Karen Hirsch, Theresa Human, Michael L James, Nerissa Ko, Daniel Kondziella, Sarah Livesay, Lori K Madden, Shraddha Mainali, Stephan A Mayer, Victoria McCredie, Molly M McNett, Geert Meyfroidt, Martin M Monti, Susanne Muehlschlegel, Santosh Murthy, Paul Nyquist, DaiWai M Olson, J Javier Provencio, Eric Rosenthal, Gisele Sampaio Silva, Simone Sarasso, Nicholas D Schiff, Tarek Sharshar, Lori Shutter, Robert D Stevens, Paul Vespa, Walter Videtta, Amy Wagner, Wendy Ziai, Curing Coma Campaign

Department of Neurology

55 Citations (Scopus)

Abstract

Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.

Original language	English
Journal	Neurocritical Care
Volume	35
Issue number	Suppl 1
Pages (from-to)	4-23
Number of pages	20
ISSN	1541-6933
DOIs	https://doi.org/10.1007/s12028-021-01260-x
Publication status	Published - Jul 2021

Keywords

Biomarkers
Coma/diagnosis
Congresses as Topic
Consciousness
Consciousness Disorders/diagnosis
Humans
National Institutes of Health (U.S.)
United States

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Claassen, J., Akbari, Y., Alexander, S., Bader, M. K., Bell, K., Bleck, T. P., Boly, M., Brown, J., Chou, S. H.-Y., Diringer, M. N., Edlow, B. L., Foreman, B., Giacino, J. T., Gosseries, O., Green, T., Greer, D. M., Hanley, D. F., Hartings, J. A., Helbok, R., ... Curing Coma Campaign (2021). Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical Care, 35(Suppl 1), 4-23. https://doi.org/10.1007/s12028-021-01260-x

Claassen, J, Akbari, Y, Alexander, S, Bader, MK, Bell, K, Bleck, TP, Boly, M, Brown, J, Chou, SH-Y, Diringer, MN, Edlow, BL, Foreman, B, Giacino, JT, Gosseries, O, Green, T, Greer, DM, Hanley, DF, Hartings, JA, Helbok, R, Hemphill, JC, Hinson, HE, Hirsch, K, Human, T, James, ML, Ko, N, Kondziella, D, Livesay, S, Madden, LK, Mainali, S, Mayer, SA, McCredie, V, McNett, MM, Meyfroidt, G, Monti, MM, Muehlschlegel, S, Murthy, S, Nyquist, P, Olson, DM, Provencio, JJ, Rosenthal, E, Sampaio Silva, G, Sarasso, S, Schiff, ND, Sharshar, T, Shutter, L, Stevens, RD, Vespa, P, Videtta, W, Wagner, A, Ziai, W & Curing Coma Campaign 2021, 'Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness', Neurocritical Care, vol. 35, no. Suppl 1, pp. 4-23. https://doi.org/10.1007/s12028-021-01260-x

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abstract = "Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.",

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Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness

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Keywords

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