Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

Mette Borre; M Dziegiel; B Høgh; E Petersen; K Rieneck; E Riley; J F Meis; M Aikawa; K Nakamura; M Harada

Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

Mette Borre
, M Dziegiel
, B Høgh
, E Petersen
, K Rieneck
, E Riley
, J F Meis
, M Aikawa
, K Nakamura
, M Harada

125 Citations (Scopus)

Abstract

A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.

Original language	English
Journal	Molecular and Biochemical Parasitology
Volume	49
Issue number	1
Pages (from-to)	119-31
Number of pages	13
ISSN	0166-6851
Publication status	Published - Nov 1991

Keywords

Amino Acid Sequence
Animals
Antigens, Protozoan
Base Sequence
Chromosome Mapping
DNA, Protozoan
Erythrocytes
Microscopy, Immunoelectron
Molecular Sequence Data
Plasmodium falciparum
Protozoan Proteins

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Borre, M., Dziegiel, M., Høgh, B., Petersen, E., Rieneck, K., Riley, E., Meis, J. F., Aikawa, M., Nakamura, K., & Harada, M. (1991). Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle. Molecular and Biochemical Parasitology, 49(1), 119-31.

Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle. / Borre, Mette; Dziegiel, M; Høgh, B et al.
In: Molecular and Biochemical Parasitology, Vol. 49, No. 1, 11.1991, p. 119-31.

Research output: Contribution to journal › Journal article › Research › peer-review

Borre, M, Dziegiel, M, Høgh, B, Petersen, E , Rieneck, K, Riley, E, Meis, JF, Aikawa, M, Nakamura, K & Harada, M 1991, 'Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle', Molecular and Biochemical Parasitology, vol. 49, no. 1, pp. 119-31.

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abstract = "A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.",

keywords = "Amino Acid Sequence, Animals, Antigens, Protozoan, Base Sequence, Chromosome Mapping, DNA, Protozoan, Erythrocytes, Microscopy, Immunoelectron, Molecular Sequence Data, Plasmodium falciparum, Protozoan Proteins",

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AU - Borre, Mette

AU - Dziegiel, M

AU - Høgh, B

AU - Petersen, E

AU - Rieneck, K

AU - Riley, E

AU - Meis, J F

AU - Aikawa, M

AU - Nakamura, K

AU - Harada, M

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N2 - A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.

AB - A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, Protozoan

KW - Base Sequence

KW - Chromosome Mapping

KW - DNA, Protozoan

KW - Erythrocytes

KW - Microscopy, Immunoelectron

KW - Molecular Sequence Data

KW - Plasmodium falciparum

KW - Protozoan Proteins

M3 - Journal article

C2 - 1775153

SN - 0166-6851

VL - 49

SP - 119

EP - 131

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

IS - 1

ER -