Primary immunization-like response without hepatitis following transfusion of HBeAg-positive blood

C Gluud, J Aldershvile, P Kryger, E Dybkjaer, J O Nielsen

3 Citations (Scopus)

Abstract

An accidental transfusion of hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive whole blood was given to a 19-yr-old male, bleeding after tonsillectomy. Serum obtained from the patient before the transfusion revealed no hepatitis B antigens or antibodies. After the transfusion the patient became HBsAg-positive, cleared this antigen and developed antibodies to both HBsAg and HBeAg. The transfusion blood was positive for total antibody and IgM antibody to hepatitis B core antigen (HBcAg). The patient's blood became positive for these antibodies after the transfusion, but with declining titres. Liver tests were normal through the entire follow-up. The serological and clinical course suggests immunisation to passively transferred antigens without hepatitis.
Original languageEnglish
JournalScandinavian Journal of Infectious Diseases
Volume15
Issue number4
Pages (from-to)399-401
Number of pages3
ISSN0036-5548
Publication statusPublished - 1983

Keywords

  • Adult
  • Blood Transfusion
  • Hemorrhage
  • Hepatitis B Antigens
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
  • Humans
  • Immunization, Passive
  • Male
  • Postoperative Complications
  • Tonsillectomy

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