Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.:

T L Nielsen; Birgitte Nybo Jensen; S Nelsing; C Pedersen; Lars Reinhardt Mathiesen; P Skinhøj; Jens Ole Nielsen

Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.

T L Nielsen, Birgitte Nybo Jensen, S Nelsing, C Pedersen, Lars Reinhardt Mathiesen, P Skinhøj, Jens Ole Nielsen

Abstract

The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of PCP occurred in eight patients; four episodes were histologically verified and four episodes were clinically assumed. The relapse rate after one year of prophylaxis was 5.1% (95% CI 0.0%-11.0%) using the log-rank test. Intolerance of secondary prophylaxis, defined as adverse effects necessitating cessation of SP with SMX-TMP, was reported in eight patients (5%) (95% CI 2.1%-9.3%).

Translated title of the contribution	Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.
Original language	English
Journal	Danish Medical Bulletin
Volume	40
Issue number	4
Pages (from-to)	503-505
Number of pages	3
ISSN	0907-8916
Publication status	Published - 1993

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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8222772&query_hl=60

Cite this

Nielsen, T. L., Jensen, B. N., Nelsing, S., Pedersen, C., Mathiesen, L. R., Skinhøj, P., & Nielsen, J. O. (1993). Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim. Danish Medical Bulletin, 40(4), 503-505. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8222772&query_hl=60

Nielsen, TL, Jensen, BN, Nelsing, S, Pedersen, C, Mathiesen, LR, Skinhøj, P & Nielsen, JO 1993, 'Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.', Danish Medical Bulletin, vol. 40, no. 4, pp. 503-505. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8222772&query_hl=60>

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title = "Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.",

abstract = "The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of PCP occurred in eight patients; four episodes were histologically verified and four episodes were clinically assumed. The relapse rate after one year of prophylaxis was 5.1\% (95\% CI 0.0\%-11.0\%) using the log-rank test. Intolerance of secondary prophylaxis, defined as adverse effects necessitating cessation of SP with SMX-TMP, was reported in eight patients (5\%) (95\% CI 2.1\%-9.3\%).",

author = "Nielsen, \{T L\} and Jensen, \{Birgitte Nybo\} and S Nelsing and C Pedersen and Mathiesen, \{Lars Reinhardt\} and P Skinh{\o}j and Nielsen, \{Jens Ole\}",

year = "1993",

language = "English",

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T1 - Prevention of Pneumocystis carinii pneumonia relapse in AIDS patients. The efficacy and tolerability of low-dose sulfamethoxazole-trimethoprim.

AU - Nielsen, T L

AU - Jensen, Birgitte Nybo

AU - Nelsing, S

AU - Pedersen, C

AU - Mathiesen, Lars Reinhardt

AU - Skinhøj, P

AU - Nielsen, Jens Ole

PY - 1993

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N2 - The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of PCP occurred in eight patients; four episodes were histologically verified and four episodes were clinically assumed. The relapse rate after one year of prophylaxis was 5.1% (95% CI 0.0%-11.0%) using the log-rank test. Intolerance of secondary prophylaxis, defined as adverse effects necessitating cessation of SP with SMX-TMP, was reported in eight patients (5%) (95% CI 2.1%-9.3%).

AB - The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of PCP occurred in eight patients; four episodes were histologically verified and four episodes were clinically assumed. The relapse rate after one year of prophylaxis was 5.1% (95% CI 0.0%-11.0%) using the log-rank test. Intolerance of secondary prophylaxis, defined as adverse effects necessitating cessation of SP with SMX-TMP, was reported in eight patients (5%) (95% CI 2.1%-9.3%).

M3 - Journal article

SN - 0907-8916

VL - 40

SP - 503

EP - 505

JO - Danish Medical Bulletin

JF - Danish Medical Bulletin

IS - 4

ER -