Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Lu Li; Masahiro Itoh; Maila Ablake; Battesimo Macrì; Klaus Bendtzen; Ferdinando Nicoletti

doi:10.1006/clim.2001.5155

Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Lu Li, Masahiro Itoh, Maila Ablake, Battesimo Macrì, Klaus Bendtzen, Ferdinando Nicoletti

16 Citations (Scopus)

Abstract

We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.

Original language	English
Journal	Clinical Immunology
Volume	102
Issue number	2
Pages (from-to)	135-7
Number of pages	3
ISSN	1521-6616
DOIs	https://doi.org/10.1006/clim.2001.5155
Publication status	Published - 1 Feb 2002
Externally published	Yes

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abstract = "We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.",

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AU - Li, Lu

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AU - Bendtzen, Klaus

AU - Nicoletti, Ferdinando

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AB - We studied the effect of exogenously administered recombinant human interleukin (IL)-6 on the development of experimental autoimmune orchitis (EAO) in C3H/Hej mice. IL-6 significantly reduced histological signs of EAO and appearance of delayed type hypersensitivity against the immunizing testicular germinal cells. The effect was seen even though the cytokine was administered for only 6 consecutive days and 2 weeks after immunization.

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Prevention of murine experimental autoimmune orchitis by recombinant human interleukin-6

Abstract

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