Prevention of carrageenan-induced pleurisy in mice by anti-CD30 ligand monoclonal antibody

Rosanna Di Paola, Roberto Di Marco, Emanuela Mazzon, Tiziana Genovese, Klaus Bendtzen, Battesimo Macrì, Ferdinando Nicoletti, Salvatore Cuzzocrea

    12 Citations (Scopus)

    Abstract

    CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-alpha play a key pathogenic role. The data show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
    Original languageEnglish
    JournalClinical Immunology
    Volume113
    Issue number1
    Pages (from-to)64-73
    Number of pages10
    ISSN1521-6616
    DOIs
    Publication statusPublished - 1 Oct 2004

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