Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14

F Nicoletti; R Di Marco; P Sacerdote; P Meroni; K Mangano; Louise Christina Edwards; A Bartorelli; K Bendtzen; A Panerai

doi:10.1128/AAC.45.5.1591-1594.2001

Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14

F Nicoletti, R Di Marco, P Sacerdote, P Meroni, K Mangano, Louise Christina Edwards, A Bartorelli, K Bendtzen, A Panerai

2 Citations (Scopus)

Abstract

Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	45
Issue number	5
Pages (from-to)	1591-4
Number of pages	4
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.45.5.1591-1594.2001
Publication status	Published - 1 May 2001

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10.1128/AAC.45.5.1591-1594.2001

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title = "Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14",

abstract = "Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.",

author = "F Nicoletti and \{Di Marco\}, R and P Sacerdote and P Meroni and K Mangano and Edwards, \{Louise Christina\} and A Bartorelli and K Bendtzen and A Panerai",

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AU - Nicoletti, F

AU - Di Marco, R

AU - Sacerdote, P

AU - Meroni, P

AU - Mangano, K

AU - Edwards, Louise Christina

AU - Bartorelli, A

AU - Bendtzen, K

AU - Panerai, A

PY - 2001/5/1

Y1 - 2001/5/1

N2 - Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.

AB - Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.

UR - https://www.scopus.com/pages/publications/0035038580

U2 - 10.1128/AAC.45.5.1591-1594.2001

DO - 10.1128/AAC.45.5.1591-1594.2001

M3 - Journal article

C2 - 11302837

SN - 0066-4804

VL - 45

SP - 1591

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14

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