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PREVALENCE OF HUMAN PAPILLOMAVIRUS IN SELF-TAKEN SAMPLES FROM SCREENING NON-ATTENDERS

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@article{e7689bb21c8a4269a3978cc92e99235e,
title = "PREVALENCE OF HUMAN PAPILLOMAVIRUS IN SELF-TAKEN SAMPLES FROM SCREENING NON-ATTENDERS",
abstract = "The Copenhagen Self-sampling Initiative (CSi) has shown how Human Papillomavirus (HPV)-based self-sampling can be used to increase screening participation among 23,632 non-attenders in Capital Region of Denmark. Here, we described the HPV prevalence and genotype frequency in 4824 self-samples using three HPV assays (CLART, Onclarity and HC2), and compared the results to the subsequent physician-taken follow-up samples. HPV self-sample findings were also compared to a reference population of routinely screened women (N=3347, from the Horizon study), undertaken in the same screening laboratory. Non-attenders had an HPV prevalence of 11.3% based on CLART, which was lower than women from Horizon (18.5%). One-third of the CSi women who tested HPV positive by self-sampling, were HPV negative in the subsequent physician-taken follow-up sample. CLART and Onclarity agreed in 64% (95%CI: 60-68%) of the HPV positive self-samples. Adding HC2 into a three-way comparison, the agreement decreased to 27% (95% CI: 24-29%). Our findings suggest that further validation of HPV assays for self-taken samples is needed for optimal HPV detection and correct clinical management of HPV positive women.",
keywords = "Journal Article",
author = "{Uyen Hoa Lam}, Janni and M Rebolj and Ejegod, {D M} and H Pedersen and C Rygaard and E. Lynge and E Harder and Thomsen, {L T} and Kjaer, {S K} and J Bonde",
note = "Copyright {\textcopyright} 2017 Lam et al.",
year = "2017",
month = oct,
doi = "10.1128/JCM.00550-17",
language = "English",
volume = "55",
pages = "2913--2923",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "10",

}

RIS

TY - JOUR

T1 - PREVALENCE OF HUMAN PAPILLOMAVIRUS IN SELF-TAKEN SAMPLES FROM SCREENING NON-ATTENDERS

AU - Uyen Hoa Lam , Janni

AU - Rebolj, M

AU - Ejegod, D M

AU - Pedersen, H

AU - Rygaard, C

AU - Lynge, E.

AU - Harder, E

AU - Thomsen, L T

AU - Kjaer, S K

AU - Bonde, J

N1 - Copyright © 2017 Lam et al.

PY - 2017/10

Y1 - 2017/10

N2 - The Copenhagen Self-sampling Initiative (CSi) has shown how Human Papillomavirus (HPV)-based self-sampling can be used to increase screening participation among 23,632 non-attenders in Capital Region of Denmark. Here, we described the HPV prevalence and genotype frequency in 4824 self-samples using three HPV assays (CLART, Onclarity and HC2), and compared the results to the subsequent physician-taken follow-up samples. HPV self-sample findings were also compared to a reference population of routinely screened women (N=3347, from the Horizon study), undertaken in the same screening laboratory. Non-attenders had an HPV prevalence of 11.3% based on CLART, which was lower than women from Horizon (18.5%). One-third of the CSi women who tested HPV positive by self-sampling, were HPV negative in the subsequent physician-taken follow-up sample. CLART and Onclarity agreed in 64% (95%CI: 60-68%) of the HPV positive self-samples. Adding HC2 into a three-way comparison, the agreement decreased to 27% (95% CI: 24-29%). Our findings suggest that further validation of HPV assays for self-taken samples is needed for optimal HPV detection and correct clinical management of HPV positive women.

AB - The Copenhagen Self-sampling Initiative (CSi) has shown how Human Papillomavirus (HPV)-based self-sampling can be used to increase screening participation among 23,632 non-attenders in Capital Region of Denmark. Here, we described the HPV prevalence and genotype frequency in 4824 self-samples using three HPV assays (CLART, Onclarity and HC2), and compared the results to the subsequent physician-taken follow-up samples. HPV self-sample findings were also compared to a reference population of routinely screened women (N=3347, from the Horizon study), undertaken in the same screening laboratory. Non-attenders had an HPV prevalence of 11.3% based on CLART, which was lower than women from Horizon (18.5%). One-third of the CSi women who tested HPV positive by self-sampling, were HPV negative in the subsequent physician-taken follow-up sample. CLART and Onclarity agreed in 64% (95%CI: 60-68%) of the HPV positive self-samples. Adding HC2 into a three-way comparison, the agreement decreased to 27% (95% CI: 24-29%). Our findings suggest that further validation of HPV assays for self-taken samples is needed for optimal HPV detection and correct clinical management of HPV positive women.

KW - Journal Article

U2 - 10.1128/JCM.00550-17

DO - 10.1128/JCM.00550-17

M3 - Journal article

C2 - 28724554

VL - 55

SP - 2913

EP - 2923

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 10

ER -

ID: 51508270