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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Prevalence of Herpes -, Measles morbillivirus-, Parvovirus B19 - and Rubella viruses Immunoglobulin G among women with chronic Hepatitis B of reproductive age in Denmark: A cross-sectional study

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OBJECTIVES: The aim of this study was to investigate whether the seroprevalence of IgG antibodies against seven viruses (cytomegalovirus, herpes simplex virus 1&2, measles morbillivirus, parvovirus B19, rubella and varicella-zoster virus), which can potentially compromise maternal and fetal wellbeing, differs based on country of origin among women with chronic Hepatitis B (CHB).

METHOD: This study was a single-center, hospital based cross-sectional study. The study included women with CHB 15-45 years of age, included in the Danish Database for Hepatitis B and C. Seroprevalence estimates were calculated with a 95% confidence interval and were compared between age groups, regions of origin and to the general population.

RESULTS: 177 women were included in the study. Overall, the seroprevalences of antibodies were similar among women with CHB with origin outside Denmark and compared to the general population in Denmark, but there was a notable difference in the seroprevalence of antibodies against herpes simplex 2 between women from Africa (37.1% CI 95% 22.0;55.1) and women from the Middle East (2.5% CI 95% 0.1;14.7).

CONCLUSION: Women with CHB with origin outside Denmark do not appear to differ based on origin or be at greater risk of acquiring these viruses during pregnancy compared to the Danish population.

Original languageEnglish
JournalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN1201-9712
DOIs
Publication statusE-pub ahead of print - 1 Oct 2020

ID: 60978959