Prevalence of central serous chorioretinopathy in Denmark

Ida N Frederiksen; Danson V Muttuvelu; Rodrigo Anguita; Lasse J Cehofski; Nathalie S Eriksen; Carsten Faber; Mads K Falk; Lorenzo Ferro Desideri; Giuseppe Giannaccare; Jakob Grauslund; Michael Stormly Hansen; Josef Huemer; Morten B Larsen; Ligor P Kiruparajan; Chris B Søndergaard; Andrea Taloni; Tobias E Torp-Pedersen; Elon H C van Dijk; Marie L R Rasmussen; Yousif Subhi

doi:10.1111/aos.17520

Prevalence of central serous chorioretinopathy in Denmark

Ida N Frederiksen, Danson V Muttuvelu, Rodrigo Anguita, Lasse J Cehofski, Nathalie S Eriksen, Carsten Faber, Mads K Falk, Lorenzo Ferro Desideri, Giuseppe Giannaccare, Jakob Grauslund, Michael Stormly Hansen, Josef Huemer, Morten B Larsen, Ligor P Kiruparajan, Chris B Søndergaard, Andrea Taloni, Tobias E Torp-Pedersen, Elon H C van Dijk, Marie L R Rasmussen, Yousif Subhi^*

^*Corresponding author for this work

Department of Ophthalmology

5 Citations (Scopus)

Abstract

PURPOSE: Central serous chorioretinopathy (CSC) is a prevalent maculopathy, but epidemiological studies are few. In this study, we determined the prevalence of CSC for the first time in a Scandinavian population.

METHODS: This cross-sectional study was based on nationwide opportunistic retinal examination from 79 high street chain optician stores in Denmark. Retinal imaging was made using non-mydriatic colour fundus photography. Any abnormal result in the optometrist-facilitated retinal examination was referred to tele-ophthalmologic evaluation, which was performed by experienced consultant ophthalmologists who diagnosed CSC.

RESULTS: During the 4-year study period, a total of 968 610 unique individuals underwent retinal examination, which corresponded to 16.3% of the entire population of Denmark. Of these, 113 individuals were diagnosed with CSC, which corresponded to a prevalence of 14 per 100 000. Individuals with CSC presented at a mean age of 48.2 ± 12.3 years; however, CSC was present in a large age range as both teenagers and the elderly with CSC were identified. Male biological sex was a statistically significant risk factor (odds ratio: 2.33; 95% confidence interval: 1.64-3.33, p < 0.0001). By extrapolating prevalence numbers to population statistics, we estimate that 219 females and 511 males had CSC in Denmark in December 2022.

CONCLUSION: We identified a prevalence of 14 per 100 000, confirmed male biological sex as a significant risk factor for CSC, and found that the disease most commonly occurs among individuals aged 30-60 years. Further studies with multimodal imaging including optical coherence tomography are warranted for better accuracy.

Original language	English
Journal	Acta Ophthalmologica (Online)
Volume	103
Issue number	7
Pages (from-to)	776-781
Number of pages	6
ISSN	1755-3768
DOIs	https://doi.org/10.1111/aos.17520
Publication status	Published - Nov 2025

Keywords

Denmark
central serous chorioretinopathy
epidemiology
prevalence

Access to Document

10.1111/aos.17520Licence: CC BY

Cite this

Frederiksen, I. N., Muttuvelu, D. V., Anguita, R., Cehofski, L. J., Eriksen, N. S., Faber, C., Falk, M. K., Ferro Desideri, L., Giannaccare, G., Grauslund, J., Hansen, M. S., Huemer, J., Larsen, M. B., Kiruparajan, L. P., Søndergaard, C. B., Taloni, A., Torp-Pedersen, T. E., van Dijk, E. H. C., Rasmussen, M. L. R., & Subhi, Y. (2025). Prevalence of central serous chorioretinopathy in Denmark. Acta Ophthalmologica (Online), 103(7), 776-781. https://doi.org/10.1111/aos.17520

Frederiksen, IN, Muttuvelu, DV, Anguita, R, Cehofski, LJ, Eriksen, NS , Faber, C, Falk, MK, Ferro Desideri, L, Giannaccare, G, Grauslund, J, Hansen, MS, Huemer, J, Larsen, MB, Kiruparajan, LP, Søndergaard, CB, Taloni, A, Torp-Pedersen, TE, van Dijk, EHC, Rasmussen, MLR & Subhi, Y 2025, 'Prevalence of central serous chorioretinopathy in Denmark', Acta Ophthalmologica (Online), vol. 103, no. 7, pp. 776-781. https://doi.org/10.1111/aos.17520

@article{7719f4c669fc4e5db976dbfbf55e090e,

title = "Prevalence of central serous chorioretinopathy in Denmark",

abstract = "PURPOSE: Central serous chorioretinopathy (CSC) is a prevalent maculopathy, but epidemiological studies are few. In this study, we determined the prevalence of CSC for the first time in a Scandinavian population.METHODS: This cross-sectional study was based on nationwide opportunistic retinal examination from 79 high street chain optician stores in Denmark. Retinal imaging was made using non-mydriatic colour fundus photography. Any abnormal result in the optometrist-facilitated retinal examination was referred to tele-ophthalmologic evaluation, which was performed by experienced consultant ophthalmologists who diagnosed CSC.RESULTS: During the 4-year study period, a total of 968 610 unique individuals underwent retinal examination, which corresponded to 16.3\% of the entire population of Denmark. Of these, 113 individuals were diagnosed with CSC, which corresponded to a prevalence of 14 per 100 000. Individuals with CSC presented at a mean age of 48.2 ± 12.3 years; however, CSC was present in a large age range as both teenagers and the elderly with CSC were identified. Male biological sex was a statistically significant risk factor (odds ratio: 2.33; 95\% confidence interval: 1.64-3.33, p < 0.0001). By extrapolating prevalence numbers to population statistics, we estimate that 219 females and 511 males had CSC in Denmark in December 2022.CONCLUSION: We identified a prevalence of 14 per 100 000, confirmed male biological sex as a significant risk factor for CSC, and found that the disease most commonly occurs among individuals aged 30-60 years. Further studies with multimodal imaging including optical coherence tomography are warranted for better accuracy.",

keywords = "Denmark, central serous chorioretinopathy, epidemiology, prevalence",

author = "Frederiksen, \{Ida N\} and Muttuvelu, \{Danson V\} and Rodrigo Anguita and Cehofski, \{Lasse J\} and Eriksen, \{Nathalie S\} and Carsten Faber and Falk, \{Mads K\} and \{Ferro Desideri\}, Lorenzo and Giuseppe Giannaccare and Jakob Grauslund and Hansen, \{Michael Stormly\} and Josef Huemer and Larsen, \{Morten B\} and Kiruparajan, \{Ligor P\} and S{\o}ndergaard, \{Chris B\} and Andrea Taloni and Torp-Pedersen, \{Tobias E\} and \{van Dijk\}, \{Elon H C\} and Rasmussen, \{Marie L R\} and Yousif Subhi",

note = "{\textcopyright} 2025 The Author(s). Acta Ophthalmologica published by John Wiley \& Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.",

year = "2025",

month = nov,

doi = "10.1111/aos.17520",

language = "English",

volume = "103",

pages = "776--781",

journal = "Acta Ophthalmologica (Online)",

issn = "1755-3768",

publisher = "Wiley-Blackwell Publishing, Inc",

number = "7",

}

TY - JOUR

T1 - Prevalence of central serous chorioretinopathy in Denmark

AU - Frederiksen, Ida N

AU - Muttuvelu, Danson V

AU - Anguita, Rodrigo

AU - Cehofski, Lasse J

AU - Eriksen, Nathalie S

AU - Faber, Carsten

AU - Falk, Mads K

AU - Ferro Desideri, Lorenzo

AU - Giannaccare, Giuseppe

AU - Grauslund, Jakob

AU - Hansen, Michael Stormly

AU - Huemer, Josef

AU - Larsen, Morten B

AU - Kiruparajan, Ligor P

AU - Søndergaard, Chris B

AU - Taloni, Andrea

AU - Torp-Pedersen, Tobias E

AU - van Dijk, Elon H C

AU - Rasmussen, Marie L R

AU - Subhi, Yousif

PY - 2025/11

Y1 - 2025/11

N2 - PURPOSE: Central serous chorioretinopathy (CSC) is a prevalent maculopathy, but epidemiological studies are few. In this study, we determined the prevalence of CSC for the first time in a Scandinavian population.METHODS: This cross-sectional study was based on nationwide opportunistic retinal examination from 79 high street chain optician stores in Denmark. Retinal imaging was made using non-mydriatic colour fundus photography. Any abnormal result in the optometrist-facilitated retinal examination was referred to tele-ophthalmologic evaluation, which was performed by experienced consultant ophthalmologists who diagnosed CSC.RESULTS: During the 4-year study period, a total of 968 610 unique individuals underwent retinal examination, which corresponded to 16.3% of the entire population of Denmark. Of these, 113 individuals were diagnosed with CSC, which corresponded to a prevalence of 14 per 100 000. Individuals with CSC presented at a mean age of 48.2 ± 12.3 years; however, CSC was present in a large age range as both teenagers and the elderly with CSC were identified. Male biological sex was a statistically significant risk factor (odds ratio: 2.33; 95% confidence interval: 1.64-3.33, p < 0.0001). By extrapolating prevalence numbers to population statistics, we estimate that 219 females and 511 males had CSC in Denmark in December 2022.CONCLUSION: We identified a prevalence of 14 per 100 000, confirmed male biological sex as a significant risk factor for CSC, and found that the disease most commonly occurs among individuals aged 30-60 years. Further studies with multimodal imaging including optical coherence tomography are warranted for better accuracy.

AB - PURPOSE: Central serous chorioretinopathy (CSC) is a prevalent maculopathy, but epidemiological studies are few. In this study, we determined the prevalence of CSC for the first time in a Scandinavian population.METHODS: This cross-sectional study was based on nationwide opportunistic retinal examination from 79 high street chain optician stores in Denmark. Retinal imaging was made using non-mydriatic colour fundus photography. Any abnormal result in the optometrist-facilitated retinal examination was referred to tele-ophthalmologic evaluation, which was performed by experienced consultant ophthalmologists who diagnosed CSC.RESULTS: During the 4-year study period, a total of 968 610 unique individuals underwent retinal examination, which corresponded to 16.3% of the entire population of Denmark. Of these, 113 individuals were diagnosed with CSC, which corresponded to a prevalence of 14 per 100 000. Individuals with CSC presented at a mean age of 48.2 ± 12.3 years; however, CSC was present in a large age range as both teenagers and the elderly with CSC were identified. Male biological sex was a statistically significant risk factor (odds ratio: 2.33; 95% confidence interval: 1.64-3.33, p < 0.0001). By extrapolating prevalence numbers to population statistics, we estimate that 219 females and 511 males had CSC in Denmark in December 2022.CONCLUSION: We identified a prevalence of 14 per 100 000, confirmed male biological sex as a significant risk factor for CSC, and found that the disease most commonly occurs among individuals aged 30-60 years. Further studies with multimodal imaging including optical coherence tomography are warranted for better accuracy.

KW - Denmark

KW - central serous chorioretinopathy

KW - epidemiology

KW - prevalence

UR - https://www.scopus.com/pages/publications/105004751824

U2 - 10.1111/aos.17520

DO - 10.1111/aos.17520

M3 - Journal article

C2 - 40350967

SN - 1755-3768

VL - 103

SP - 776

EP - 781

JO - Acta Ophthalmologica (Online)

JF - Acta Ophthalmologica (Online)

IS - 7

ER -

Prevalence of central serous chorioretinopathy in Denmark

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this