Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Nanna Ravnborg; Danni Ambikaibalan; Gaurav Agnihotri; Shmuel Price; Supriya Rastogi; Kevin R Patel; Vivek Singam; Yuki Andersen; Anne-Sofie Halling; Jonathan I Silverberg; Alexander Egeberg; Jacob P Thyssen

doi:10.1016/j.jaad.2020.02.055

Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

Nanna Ravnborg, Danni Ambikaibalan, Gaurav Agnihotri, Shmuel Price, Supriya Rastogi, Kevin R Patel, Vivek Singam, Yuki Andersen, Anne-Sofie Halling, Jonathan I Silverberg, Alexander Egeberg, Jacob P Thyssen

47 Citations (Scopus)

Abstract

BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).

OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.

METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.

RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).

LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.

CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	84
Issue number	2
Pages (from-to)	471-478
Number of pages	8
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2020.02.055
Publication status	Published - Feb 2021

Keywords

association
asthma
atopic dermatitis
eczema
meta-analysis
prevalence
systematic review

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10.1016/j.jaad.2020.02.055

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Ravnborg, N., Ambikaibalan, D., Agnihotri, G., Price, S., Rastogi, S., Patel, K. R., Singam, V., Andersen, Y., Halling, A.-S., Silverberg, J. I., Egeberg, A., & Thyssen, J. P. (2021). Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis. Journal of the American Academy of Dermatology, 84(2), 471-478. https://doi.org/10.1016/j.jaad.2020.02.055

Ravnborg, N, Ambikaibalan, D, Agnihotri, G, Price, S, Rastogi, S, Patel, KR, Singam, V, Andersen, Y, Halling, A-S, Silverberg, JI, Egeberg, A & Thyssen, JP 2021, 'Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis', Journal of the American Academy of Dermatology, vol. 84, no. 2, pp. 471-478. https://doi.org/10.1016/j.jaad.2020.02.055

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abstract = "BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.",

keywords = "association, asthma, atopic dermatitis, eczema, meta-analysis, prevalence, systematic review",

author = "Nanna Ravnborg and Danni Ambikaibalan and Gaurav Agnihotri and Shmuel Price and Supriya Rastogi and Patel, {Kevin R} and Vivek Singam and Yuki Andersen and Anne-Sofie Halling and Silverberg, {Jonathan I} and Alexander Egeberg and Thyssen, {Jacob P}",

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AU - Ravnborg, Nanna

AU - Ambikaibalan, Danni

AU - Agnihotri, Gaurav

AU - Price, Shmuel

AU - Rastogi, Supriya

AU - Patel, Kevin R

AU - Singam, Vivek

AU - Andersen, Yuki

AU - Halling, Anne-Sofie

AU - Silverberg, Jonathan I

AU - Egeberg, Alexander

AU - Thyssen, Jacob P

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N2 - BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

AB - BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

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JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

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Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

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