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Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis

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Ravnborg, Nanna ; Ambikaibalan, Danni ; Agnihotri, Gaurav ; Price, Shmuel ; Rastogi, Supriya ; Patel, Kevin R ; Singam, Vivek ; Andersen, Yuki ; Halling, Anne-Sofie ; Silverberg, Jonathan I ; Egeberg, Alexander ; Thyssen, Jacob P. / Prevalence of asthma in patients with atopic dermatitis : A systematic review and meta-analysis. In: Journal of the American Academy of Dermatology. 2021 ; Vol. 84, No. 2. pp. 471-478.

Bibtex

@article{22a3bf3fee8945a58e5dd2b3837ff642,
title = "Prevalence of asthma in patients with atopic dermatitis: A systematic review and meta-analysis",
abstract = "BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.",
keywords = "association, asthma, atopic dermatitis, eczema, meta-analysis, prevalence, systematic review",
author = "Nanna Ravnborg and Danni Ambikaibalan and Gaurav Agnihotri and Shmuel Price and Supriya Rastogi and Patel, {Kevin R} and Vivek Singam and Yuki Andersen and Anne-Sofie Halling and Silverberg, {Jonathan I} and Alexander Egeberg and Thyssen, {Jacob P}",
note = "Copyright {\textcopyright} 2020 American Academy of Dermatology, Inc. All rights reserved.",
year = "2021",
month = feb,
doi = "10.1016/j.jaad.2020.02.055",
language = "English",
volume = "84",
pages = "471--478",
journal = "American Academy of Dermatology. Journal",
issn = "0190-9622",
publisher = "Mosby, Inc",
number = "2",

}

RIS

TY - JOUR

T1 - Prevalence of asthma in patients with atopic dermatitis

T2 - A systematic review and meta-analysis

AU - Ravnborg, Nanna

AU - Ambikaibalan, Danni

AU - Agnihotri, Gaurav

AU - Price, Shmuel

AU - Rastogi, Supriya

AU - Patel, Kevin R

AU - Singam, Vivek

AU - Andersen, Yuki

AU - Halling, Anne-Sofie

AU - Silverberg, Jonathan I

AU - Egeberg, Alexander

AU - Thyssen, Jacob P

N1 - Copyright © 2020 American Academy of Dermatology, Inc. All rights reserved.

PY - 2021/2

Y1 - 2021/2

N2 - BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

AB - BACKGROUND: It is well established that asthma is common in patients with atopic dermatitis (AD).OBJECTIVES: We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.METHODS: At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.RESULTS: The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).LIMITATIONS: The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.CONCLUSIONS: Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

KW - association

KW - asthma

KW - atopic dermatitis

KW - eczema

KW - meta-analysis

KW - prevalence

KW - systematic review

UR - http://www.scopus.com/inward/record.url?scp=85099213714&partnerID=8YFLogxK

U2 - 10.1016/j.jaad.2020.02.055

DO - 10.1016/j.jaad.2020.02.055

M3 - Review

C2 - 32112994

VL - 84

SP - 471

EP - 478

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

SN - 0190-9622

IS - 2

ER -

ID: 61783763