Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Prevalence of anti-Hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hepatitis E virus epidemiology among HIV-infected women in an urban area in Tanzania

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Incidence of HACEK bacteraemia in Denmark: A 6-year population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High incidence of candidaemia in a nationwide cohort: underlying diseases, risk factors and mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Quantification of sexual HIV transmission risk in Africa

    Research output: Contribution to journalEditorialResearchpeer-review

  5. Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Hepatitis E virus (HEV)genotype 3 is endemic in Europe, and the infection is mostly subclinical or acute and self-limiting. However, persistent infection is described among HIV-infected individuals. The prevalence of antibodies against HEV (anti-HEV)among HIV-infected persons varies geographically and is unknown in Denmark. Rates of co-infection with HEV among HIV-infected individuals in Denmark over three decades, from the early 1980s to 2013, were investigated. Methods: A total of 2506 HIV-infected persons were investigated from two cohorts followed at Hvidovre Hospital, Denmark. Blood samples were tested retrospectively for anti-HEV, including samples from 2216 persons who were enrolled in a prospective clinical cohort and followed between 1995 and 2013, as well as samples from 290 persons from a historical cohort followed between 1980 and 1994. For anti-HEV seroconverting individuals, serial samples were tested for HEV RNA. Factors associated with anti-HEV status were explored using multivariable logistic regression analysis. Results: The overall HEV seroprevalence rates were stable during the 1980s, 1990s, and 2000–2013 (23.1%, 22.9%, and 23.7%, respectively). In all decades, rates of anti-HEV increased with older age, and anti-HEV seropositivity was associated with older generations, HIV risk group, and geographic origin. Persistent HEV infection was not detected in any of 57 individuals with anti-HEV seroconversion. Conclusions: HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is rare among HIV-infected individuals.

Original languageEnglish
JournalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Volume84
Pages (from-to)67-72
Number of pages6
ISSN1201-9712
DOIs
Publication statusPublished - Jul 2019

Bibliographical note

Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

    Research areas

  • HEV, HIV, Hepatitis E virus, Persistent HEV RNA, Prevalence, Immunoglobulin G/blood, Humans, Middle Aged, Risk Factors, Male, Seroepidemiologic Studies, Coinfection/epidemiology, Hepatitis Antibodies/blood, Hepatitis E virus/immunology, HIV Infections/complications, Adult, Female

ID: 57103291