Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Community-acquired meningitis caused by beta-haemolytic streptococci in adults: a nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multicenter evaluation of the new QIAstat Gastrointestinal Panel for the rapid syndromic testing of acute gastroenteritis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. In-hospital metabolite changes in infective endocarditis-a longitudinal 1H NMR-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Eradicating MRSA carriage: the impact of throat carriage and Panton-Valentine leukocidin genes on success rates

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The effect of short-course gentamicin therapy on kidney function in patients with bacteraemia-a retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Tolbert Sonda
  • Happiness Kumburu
  • Marco van Zwetselaar
  • Michael Alifrangis
  • Blandina T Mmbaga
  • Ole Lund
  • Frank M Aarestrup
  • Gibson Kibiki
View graph of relations

Emergence and spread of extended spectrum beta-lactamase (ESBL)-producing gram-negative bacteria, mainly due to CTX-M, is a major global public health problem. Patients infected with ESBL-producing gram-negative bacteria have an increased risk of treatment failure and death. We investigated the prevalence and risk factors for CTX-M gram-negative bacteria isolated from clinical specimens of patients hospitalized at a tertiary care hospital in Kilimanjaro, Tanzania. Isolated gram-negative bacteria from inpatients admitted at Kilimanjaro Christian Medical Centre (KCMC) between August 2013 and August 2015 were fully genome sequenced. The prevalence of ESBL-producing gram-negative bacteria was determined based on the presence of blaCTX-M. The odds ratio (OR) and risk factors for ESBL-producing gram-negative bacteria due to CTX-M were assessed using logistic regression models. The overall CTX-M prevalence (95% CI) was 13.6% (10.1-18.1). Adjusted for other factors, the OR of CTX-M gram-negative bacteria for patients previously hospitalized was 0.26 (0.08-0.88), p = 0.031; the OR for patients currently on antibiotics was 4.02 (1.29-12.58), p = 0.017; the OR for patients currently on ceftriaxone was 0.14 (0.04-0.46), p = 0.001; and the OR for patients with wound infections was 0.24 (0.09-0.61), p = 0.003. The prevalence of ESBL-producing gram-negative bacteria due to CTX-M in this setting is relatively low compared to other previous reports in similar settings. However, to properly stop further spread in the hospital, we recommend setting up a hospital surveillance system that takes full advantage of the available next-generation sequencing facility to routinely screen for all types of bacterial resistance genes.

Original languageEnglish
JournalEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Volume37
Issue number5
Pages (from-to)897-906
Number of pages10
ISSN0934-9723
DOIs
Publication statusPublished - May 2018

    Research areas

  • Adult, Comorbidity, Cross Infection, Cross-Sectional Studies, Female, Genome, Bacterial, Gram-Negative Bacteria/drug effects, Gram-Negative Bacterial Infections/drug therapy, Humans, Male, Middle Aged, Prevalence, Public Health Surveillance, Risk Factors, Tanzania/epidemiology, Tertiary Care Centers, Whole Genome Sequencing, beta-Lactam Resistance, beta-Lactamases/genetics

ID: 56461998