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Prevalence and incidence of various Cancer subtypes in patients with heart failure vs matched controls

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  1. The cardiac isovolumetric contraction time is an independent predictor of incident heart failure in the general population

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  2. Carotid atherosclerosis markers and adverse cardiovascular events

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  3. Cardiovascular complications in patients with total cavopulmonary connection: A nationwide cohort study

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  4. Favorable five-year outcomes for heart failure diagnosed in younger patients without severe comorbidity

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  5. Quality of life and the associated risk of all-cause mortality in nonischemic heart failure

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  1. Switching from Vitamin K Antagonist to Dabigatran in Atrial Fibrillation: Differences According to Dose

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  2. Vitamin K antagonists vs. direct oral anticoagulants after transcatheter aortic valve implantation in atrial fibrillation

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  3. Pulmonary Arterial Enlargement in Well-Treated Persons With Human Immunodeficiency Virus

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  4. Left ventricular myocardial crypts: morphological patterns and prognostic implications

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BACKGROUND: Patients with heart failure (HF) may be at increased risks of cancer, but the magnitude of risk for various cancer subtypes is insufficiently investigated.

METHOD: Using the Danish Nationwide administrative databases between 1997 and 2017, we estimated the prevalence, incidence and relative risk for all-cause cancer in new-diagnosed HF vs. age and sex-matched controls (up to 5 controls per HF case) before and after adjustment for comorbidities.

RESULTS: Among the 167,633 people in the heart failure group and 837,126 individuals in the control group, there was a higher prevalence of several comorbidities, including cancer (17% vs. 10%) in the HF group; odds ratio 1.72 (1.70-1.75). Patients with heart failure also had higher cancer incidence (cancer incidence rate 3.02 [2.97-3.07] per 100 person-years), compared with controls (cancer incidence rate 1.89 [1.88-1.90]); hazards ratio 1.38 (1.36-1.40). However, after adjustment for comorbidities the increased risk of malignancy was greatly attenuated (hazards ratio 1.14 [1.12-1.16] for incident all-cause cancer) and dissipated altogether after additional adjustment for medications (multivariable adjusted hazards ratio 0.93 [0.91-0.96] for all-cause cancer). In a homogeneous cohort of patients with ischemic heart disease, the increased risk of all-cause cancer was only marginally increased after adjustment for baseline comorbidities (hazards ratio 1.05 [1.02-1.08]).

CONCLUSION: Patients with heart failure had a slightly increased risk of various cancer subtypes, but the risks were mainly driven by comorbidities.

Original languageEnglish
JournalInternational Journal of Cardiology
Volume316
Pages (from-to)209-213
Number of pages5
ISSN0167-5273
DOIs
Publication statusPublished - 1 Oct 2020

ID: 61195812