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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pre-transplant levels of ficolin-3 are associated with kidney graft survival

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  1. Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The lectin pathway of complement: advantage or disadvantage in HIV pathogenesis?

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  1. Prevalence, type distribution, and risk factors for oral HPV in Danish renal transplant recipients

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Fatal pneumococcus meningitis in a child with complement factor ficolin-3 deficiency

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Identification of the novel HLA allele, HLA-C*07:780, identified in a Danish woman

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Ficolin-3 is an initiator of the lectin complement pathway. The complement system is a mediator of the pathophysiology of graft rejection in kidney transplantation, but the role of ficolin-3 in this process is unknown. Using a prospective study design, 527 kidney transplanted patients were included. 97 blood donors served as controls. Ficolin-3, C4 and C3 were measured in pre-transplant as well as in control serum samples. In controls, deposition of ficolin-3, C4, C3 and the terminal complement complex (TCC) was measured in an assay based on acetylated albumin as matrix. The ficolin-3 levels correlated with the serum levels of C4 and C3. The serum levels of ficolin-3 correlated with the deposition of ficolin-3, C4, C3 and TCC. Survival analyses showed that high pre-transplant serum levels of ficolin-3 were associated with decreased graft survival. These results suggest an important role of ficolin-3 in the pathophysiology of kidney graft rejection.
Original languageEnglish
JournalClinical Immunology
Volume146
Issue number3
Pages (from-to)240-7
Number of pages8
ISSN1521-6616
DOIs
Publication statusPublished - Mar 2013

    Research areas

  • Adult, Case-Control Studies, Complement System Proteins, Female, Glycoproteins, Graft Survival, Humans, Kidney Transplantation, Lectins, Male, Middle Aged

ID: 39017858