Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms

David M Kristensen; John E Nielsen; Niels E Skakkebaek; Niels Graem; Grete K Jacobsen; Ewa Rajpert-De Meyts; Henrik Leffers

doi:10.1093/humrep/den010

Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms

David M Kristensen, John E Nielsen, Niels E Skakkebaek, Niels Graem, Grete K Jacobsen, Ewa Rajpert-De Meyts, Henrik Leffers

82 Citations (Scopus)

Abstract

UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency. Because of phenotypic similarities between pluripotent embryonic stem cells and testicular germ cell tumours (TGCT) and the derivation of pluripotent cells from testes, we investigated the expression of UTF-1 and REX-1 during human gonadal development and in TGCT.

Original language	English
Journal	Human reproduction (Oxford, England)
Volume	23
Issue number	4
Pages (from-to)	775-82
Number of pages	8
ISSN	0268-1161
DOIs	https://doi.org/10.1093/humrep/den010
Publication status	Published - Apr 2008

Keywords

Child
Female
Gene Expression
Gene Expression Regulation, Neoplastic
Gestational Age
Humans
Immunohistochemistry
In Situ Hybridization
Infant
Kruppel-Like Transcription Factors
Male
Neoplasms, Germ Cell and Embryonal
Nuclear Proteins
Ovary
Phenotype
Reverse Transcriptase Polymerase Chain Reaction
Testis
Trans-Activators

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title = "Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms",

abstract = "UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency. Because of phenotypic similarities between pluripotent embryonic stem cells and testicular germ cell tumours (TGCT) and the derivation of pluripotent cells from testes, we investigated the expression of UTF-1 and REX-1 during human gonadal development and in TGCT.",

keywords = "Child, Female, Gene Expression, Gene Expression Regulation, Neoplastic, Gestational Age, Humans, Immunohistochemistry, In Situ Hybridization, Infant, Kruppel-Like Transcription Factors, Male, Neoplasms, Germ Cell and Embryonal, Nuclear Proteins, Ovary, Phenotype, Reverse Transcriptase Polymerase Chain Reaction, Testis, Trans-Activators",

author = "Kristensen, {David M} and Nielsen, {John E} and Skakkebaek, {Niels E} and Niels Graem and Jacobsen, {Grete K} and {Rajpert-De Meyts}, Ewa and Henrik Leffers",

year = "2008",

month = apr,

doi = "10.1093/humrep/den010",

language = "English",

volume = "23",

pages = "775--82",

journal = "Human reproduction (Oxford, England)",

issn = "0268-1161",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms

AU - Kristensen, David M

AU - Nielsen, John E

AU - Skakkebaek, Niels E

AU - Graem, Niels

AU - Jacobsen, Grete K

AU - Rajpert-De Meyts, Ewa

AU - Leffers, Henrik

PY - 2008/4

Y1 - 2008/4

N2 - UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency. Because of phenotypic similarities between pluripotent embryonic stem cells and testicular germ cell tumours (TGCT) and the derivation of pluripotent cells from testes, we investigated the expression of UTF-1 and REX-1 during human gonadal development and in TGCT.

AB - UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency. Because of phenotypic similarities between pluripotent embryonic stem cells and testicular germ cell tumours (TGCT) and the derivation of pluripotent cells from testes, we investigated the expression of UTF-1 and REX-1 during human gonadal development and in TGCT.

KW - Child

KW - Female

KW - Gene Expression

KW - Gene Expression Regulation, Neoplastic

KW - Gestational Age

KW - Humans

KW - Immunohistochemistry

KW - In Situ Hybridization

KW - Infant

KW - Kruppel-Like Transcription Factors

KW - Male

KW - Neoplasms, Germ Cell and Embryonal

KW - Nuclear Proteins

KW - Ovary

KW - Phenotype

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Testis

KW - Trans-Activators

U2 - 10.1093/humrep/den010

DO - 10.1093/humrep/den010

M3 - Journal article

C2 - 18281244

SN - 0268-1161

VL - 23

SP - 775

EP - 782

JO - Human reproduction (Oxford, England)

JF - Human reproduction (Oxford, England)

IS - 4

ER -

Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms

Abstract

Keywords

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