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Preoperative frailty predicts postoperative outcomes in intestinal-cutaneous fistula repair

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  • Osaid Alser
  • Leon Naar
  • Mathias A Christensen
  • Noelle Saillant
  • Jonathan Parks
  • April Mendoza
  • Peter Fagenholz
  • David King
  • Haytham M A Kaafarani
  • George C Velmahos
  • Jason Fawley
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BACKGROUND: The outcomes of operative repair of intestinal-cutaneous fistulas vary widely throughout the literature. We aimed to investigate whether the modified frailty index-5 is a reliable tool to account for physiologic reserve and whether it serves as a predictor of Clavien-Dindo grade IV complications in those with intestinal-cutaneous fistulas undergoing operative repair.

METHODS: We queried the American College of Surgeons National Surgical Quality Improvement Program 2006 to 2017 database to include patients who underwent intestinal-cutaneous fistulas repair. The outcome of interest was 30-day Clavien-Dindo grade IV complications. The incidence of 30-day post-operative Clavien-Dindo grade IV complications were evaluated based on calculated modified frailty index-5 score. Multivariable logistic regression analyses were performed to assess the association of Clavien-Dindo grade IV complications and modified frailty index-5.

RESULTS: A total of 3,995 patients were identified who underwent an intestinal-cutaneous fistulas repair. The median age (interquartile range) was 57 years (46, 67), and most patients were female (2,143 [53.7%]), White (3,206 [80.3%]), and 1,512 (38.2%) were obese. After adjusting for relevant covariates such as demographics, comorbidities, and operative details, modified frailty index-5 was independently associated with Clavien-Dindo grade IV complications (odds ratio = 2.81, 95% confidence interval 1.64-4.82; P < .001).

CONCLUSION: Modified frailty index-5 is an independent predictor of Clavien-Dindo grade IV complications following intestinal-cutaneous fistulas repair. It can be used to account for physiologic reserve, thus reducing the variability of outcomes reported for intestinal-cutaneous fistulas repair.

Original languageEnglish
JournalSurgery
Volume169
Issue number5
Pages (from-to)1199-1205
Number of pages7
ISSN0039-6060
DOIs
Publication statusPublished - May 2021

ID: 65895278