Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Prenatal inflammation suppresses blood Th1 polarization and gene clusters related to cellular energy metabolism in preterm newborns

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Influence of FGF23 and Klotho on male reproduction: Systemic vs direct effects

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Preserved capacity for satellite cell proliferation, regeneration, and hypertrophy in the skeletal muscle of healthy elderly men

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Potential Benefits of Bovine Colostrum in Pediatric Nutrition and Health

    Research output: Contribution to journalReviewResearchpeer-review

  2. Plasma Metabolomics to Evaluate Progression of Necrotising Enterocolitis in Preterm Pigs

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Supplemental Insulin-Like Growth Factor-1 and Necrotizing Enterocolitis in Preterm Pigs

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Radiographic Imaging to Evaluate Food Passage Rate in Preterm Piglets as a Model for Preterm Infants

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Gut transit time, using radiological contrast imaging, to predict early signs of necrotizing enterocolitis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Chorioamnionitis (CA, fetal membrane inflammation) predisposes to preterm birth and is associated with increased neonatal infection risk, but the separate effects of prematurity, CA, and postnatal adaptations on this risk are unclear. Using pigs as models for infants, we examined the systemic immune-metabolic status in cesarean-delivered preterm pigs, with and without CA induced by intra-amniotic (IA) LPS exposure. At birth, cord blood of preterm pigs showed neutropenia and low expressions of innate and adaptive immune genes, relative to term pigs. IA LPS induced CA and fetal systemic innate immune activation via complement and neutrophil-related pathways. These were mainly modulated via cellular regulations rather than granulopoiesis, as validated by the in vitro LPS stimulation of cord blood. After birth, IA LPS-exposed preterm pigs did not follow normal immune-metabolic ontogenies found in fetuses or newborns without prenatal insults, but showed consistently high levels of Treg, impaired Th1 polarization, and reduced expressions of multiple genes related to cellular oxidative phosphorylation and ribosomal activities. In conclusion, our results provide cellular and molecular evidence for CA-induced distinct neonatal immune-metabolic status with increased disease tolerance strategy, suggesting mechanisms for the clinical observation of elevated sepsis risks in immune-compromised preterm infants born with CA.

Original languageEnglish
JournalFASEB Journal
Volume34
Issue number2
Pages (from-to)2896-2911
Number of pages16
ISSN0892-6638
DOIs
Publication statusPublished - Feb 2020

    Research areas

  • chorioamnionitis, immune development, lipopolysaccharide, neonatal sepsis, preterm infants

ID: 59419181