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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

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  1. Children's white blood cell counts in relation to developmental exposures to methylmercury and persistent organic pollutants

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  2. Use of non-prescription analgesics and male reproductive function

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  3. Environmental cadmium and lead exposure and anti-Müllerian hormone in pregnant women

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  4. Tobacco smoking during pregnancy and risk of adverse behaviour in offspring: A follow-up study

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  5. Environmental hexachlorobenzene exposure and human male reproductive function

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  1. Bilateral oophorectomy and rate of colorectal cancer: A prospective cohort study

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  2. Comprehensive Evaluation of Blood Plasma and Serum Sample Preparations for HRMS-Based Chemical Exposomics: Overlaps and Specificities

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  3. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

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  4. Paracetamol use during pregnancy - a call for precautionary action

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  5. Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study

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In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8mm (95% confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.

Original languageEnglish
JournalReproductive toxicology (Elmsford, N.Y.)
Volume68
Pages (from-to)200-206
Number of pages7
ISSN0890-6238
DOIs
Publication statusPublished - Mar 2017

    Research areas

  • Adult, Alkanesulfonic Acids, Anal Canal, Anthropometry, Cohort Studies, Denmark, Female, Fluorocarbons, Genitalia, Female, Genitalia, Male, Humans, Infant, Male, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Sex Factors, Journal Article

ID: 53620852