Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Author Correction: Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Allergen Specificity in Specific IgE Cutoff

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Allergitest hos børn: flere spørgsmål end svar

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Maternal dietary interventions during pregnancy with fish oil and high dose vitamin D have been shown to reduce the incidence of asthma and wheeze in offspring, potentially through microbial effects in pregnancy or early childhood. Here we analyze the bacterial compositions in longitudinal samples from 695 pregnant women and their children according to intervention group in a nested, factorial, double-blind, placebo-controlled, randomized trial of n-3 long-chain fatty acids and vitamin D supplementation. The dietary interventions affect the infant airways, but not the infant fecal or maternal vaginal microbiota. Changes in overall beta diversity are observed, which in turn associates with a change in immune mediator profile. In addition, airway microbial maturation and the relative abundance of specific bacterial genera are altered. Furthermore, mediation analysis reveals the changed airway microbiota to be a minor and non-significant mediator of the protective effect of the dietary interventions on risk of asthma. Our results demonstrate the potential of prenatal dietary supplements as manipulators of the early airway bacterial colonization.

Original languageEnglish
JournalNature Communications
Volume11
Issue number1
Pages (from-to)426
ISSN2041-1723
DOIs
Publication statusPublished - 22 Jan 2020

ID: 59136948