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Prehospital plasma is associated with distinct biomarker expression following injury

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Gruen, DS, Brown, JB, Guyette, FX, Vodovotz, Y, Johansson, PI, Stensballe, J, Barclay, DA, Yin, J, Daley, BJ, Miller, RS, Harbrecht, BG, Claridge, JA, Phelan, HA, Neal, MD, Zuckerbraun, B, Billiar, TR & Sperry, JL 2020, 'Prehospital plasma is associated with distinct biomarker expression following injury' JCI Insight, vol. 5, no. 8. https://doi.org/10.1172/jci.insight.135350

APA

Gruen, D. S., Brown, J. B., Guyette, F. X., Vodovotz, Y., Johansson, P. I., Stensballe, J., ... Sperry, J. L. (2020). Prehospital plasma is associated with distinct biomarker expression following injury. JCI Insight, 5(8). https://doi.org/10.1172/jci.insight.135350

CBE

Gruen DS, Brown JB, Guyette FX, Vodovotz Y, Johansson PI, Stensballe J, Barclay DA, Yin J, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Neal MD, Zuckerbraun B, Billiar TR, Sperry JL. 2020. Prehospital plasma is associated with distinct biomarker expression following injury. JCI Insight. 5(8). https://doi.org/10.1172/jci.insight.135350

MLA

Vancouver

Author

Gruen, Danielle S ; Brown, Joshua B ; Guyette, Francis X ; Vodovotz, Yoram ; Johansson, Par I ; Stensballe, Jakob ; Barclay, Derek A ; Yin, Jinling ; Daley, Brian J ; Miller, Richard S ; Harbrecht, Brian G ; Claridge, Jeffrey A ; Phelan, Herb A ; Neal, Matthew D ; Zuckerbraun, Brian ; Billiar, Timothy R ; Sperry, Jason L. / Prehospital plasma is associated with distinct biomarker expression following injury. In: JCI Insight. 2020 ; Vol. 5, No. 8.

Bibtex

@article{015415cccd8b4787a43b44c4c9274809,
title = "Prehospital plasma is associated with distinct biomarker expression following injury",
abstract = "BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomarkers of the immune response and endothelial injury. Regression analysis was used to control for differences across study and to assess any association with prehospital plasma resuscitation.RESULTSHCA distinguished two patient clusters with different injury patterns and outcomes. Patients in cluster A had greater injury severity and incidence of blunt trauma, traumatic brain injury, and mortality. Cluster A patients that received prehospital plasma showed improved 30-day survival. Prehospital plasma did not improve survival in cluster B patients. In an adjusted analysis of the most seriously injured patients, prehospital plasma was associated with an increase in adiponectin, IL-1β, IL-17A, IL-23, and IL-17E upon admission, and a reduction in syndecan-1, TM, VEGF, IL-6, IP-10, MCP-1, and TNF-α, and an increase in IL-33, IL-21, IL-23, and IL-17E 24 hours later.CONCLUSIONPrehospital plasma may ameliorate immune dysfunction and the endotheliopathy of trauma. These effects of plasma may contribute to improved survival in injured patients.TRIAL REGISTRATIONNCT01818427.FUNDINGDepartment of Defense; National Institutes of Health, U.S. Army.",
author = "Gruen, {Danielle S} and Brown, {Joshua B} and Guyette, {Francis X} and Yoram Vodovotz and Johansson, {Par I} and Jakob Stensballe and Barclay, {Derek A} and Jinling Yin and Daley, {Brian J} and Miller, {Richard S} and Harbrecht, {Brian G} and Claridge, {Jeffrey A} and Phelan, {Herb A} and Neal, {Matthew D} and Brian Zuckerbraun and Billiar, {Timothy R} and Sperry, {Jason L}",
year = "2020",
month = "4",
day = "23",
doi = "10.1172/jci.insight.135350",
language = "English",
volume = "5",
journal = "JCI Insight",
issn = "2379-3708",
publisher = "American Society for Clinical Investigation",
number = "8",

}

RIS

TY - JOUR

T1 - Prehospital plasma is associated with distinct biomarker expression following injury

AU - Gruen, Danielle S

AU - Brown, Joshua B

AU - Guyette, Francis X

AU - Vodovotz, Yoram

AU - Johansson, Par I

AU - Stensballe, Jakob

AU - Barclay, Derek A

AU - Yin, Jinling

AU - Daley, Brian J

AU - Miller, Richard S

AU - Harbrecht, Brian G

AU - Claridge, Jeffrey A

AU - Phelan, Herb A

AU - Neal, Matthew D

AU - Zuckerbraun, Brian

AU - Billiar, Timothy R

AU - Sperry, Jason L

PY - 2020/4/23

Y1 - 2020/4/23

N2 - BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomarkers of the immune response and endothelial injury. Regression analysis was used to control for differences across study and to assess any association with prehospital plasma resuscitation.RESULTSHCA distinguished two patient clusters with different injury patterns and outcomes. Patients in cluster A had greater injury severity and incidence of blunt trauma, traumatic brain injury, and mortality. Cluster A patients that received prehospital plasma showed improved 30-day survival. Prehospital plasma did not improve survival in cluster B patients. In an adjusted analysis of the most seriously injured patients, prehospital plasma was associated with an increase in adiponectin, IL-1β, IL-17A, IL-23, and IL-17E upon admission, and a reduction in syndecan-1, TM, VEGF, IL-6, IP-10, MCP-1, and TNF-α, and an increase in IL-33, IL-21, IL-23, and IL-17E 24 hours later.CONCLUSIONPrehospital plasma may ameliorate immune dysfunction and the endotheliopathy of trauma. These effects of plasma may contribute to improved survival in injured patients.TRIAL REGISTRATIONNCT01818427.FUNDINGDepartment of Defense; National Institutes of Health, U.S. Army.

AB - BACKGROUNDPrehospital plasma improves survival in severely injured patients transported by air ambulance. We hypothesized that prehospital plasma would be associated with a reduction in immune imbalance and endothelial damage.METHODSWe sampled blood from 405 trauma patients enrolled in the Prehospital Air Medical Plasma (PAMPer) trial upon hospital admission (0 hours) and 24 hours post admission across 6 U.S. sites. We assayed samples for 21 inflammatory mediators and 7 markers associated with endothelial function and damage. We performed hierarchical clustering analysis (HCA) of these biomarkers of the immune response and endothelial injury. Regression analysis was used to control for differences across study and to assess any association with prehospital plasma resuscitation.RESULTSHCA distinguished two patient clusters with different injury patterns and outcomes. Patients in cluster A had greater injury severity and incidence of blunt trauma, traumatic brain injury, and mortality. Cluster A patients that received prehospital plasma showed improved 30-day survival. Prehospital plasma did not improve survival in cluster B patients. In an adjusted analysis of the most seriously injured patients, prehospital plasma was associated with an increase in adiponectin, IL-1β, IL-17A, IL-23, and IL-17E upon admission, and a reduction in syndecan-1, TM, VEGF, IL-6, IP-10, MCP-1, and TNF-α, and an increase in IL-33, IL-21, IL-23, and IL-17E 24 hours later.CONCLUSIONPrehospital plasma may ameliorate immune dysfunction and the endotheliopathy of trauma. These effects of plasma may contribute to improved survival in injured patients.TRIAL REGISTRATIONNCT01818427.FUNDINGDepartment of Defense; National Institutes of Health, U.S. Army.

U2 - 10.1172/jci.insight.135350

DO - 10.1172/jci.insight.135350

M3 - Journal article

VL - 5

JO - JCI Insight

JF - JCI Insight

SN - 2379-3708

IS - 8

ER -

ID: 59672511