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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Pregnancy outcomes after recurrent pregnancy loss: a longitudinal cohort study on stress and depression

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Research Question
Are self-reported symptoms of stress and depression associated with pregnancy outcomes within the first year after referral to a tertiary recurrent pregnancy loss unit?
Design
Prospective cohort study with online questionnaires using the Major Depression Inventory (MDI) and Cohen's Stress Scale (PSS) at referral and after one year. The study was conducted between 2010 and 2014. A total of 301 women with recurrent pregnancy loss completed the first questionnaire. One year after referral, 185 women (61%) completed a follow-up questionnaire.
Results
A score above the threshold for major depression on the MDI at referral was not a predictor for outcome in the first pregnancy after referral; OR (95% CI) for live birth 1.71 (0.66; 4.44), nor was increasing scores on the PSS: OR 0.98 (95% CI 0.94; 1.02). At follow-up, women who had achieved a pregnancy which ended with the birth of a live born child had significantly lower scores on both the MDI: 13.45 (11.05) versus 11.04 (11.07), difference -2.41 (95% CI -4.60; -0.23) and the PSS: mean 17.69 (7.59) versus 13.03 (6.83), difference -4.66 (95% CI -6.04; -3.28), respectively. This was not the case for women who did not have a successful pregnancy. Women with recurrent pregnancy loss after a child were less likely to report symptoms corresponding to major depression than women with only losses (n=7 (5%) vs. 19 (12%), p=0.04).
Conclusions
Self-reported emotional distress did not impact future chance of live birth in this cohort. A live born child decreased emotional distress.
Original languageDanish
JournalReproductive BioMedicine Online
ISSN1472-6483
DOIs
Publication statusPublished - 1 Apr 2019

ID: 56241316