Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Pre-eclampsia and risk of later kidney disease: nationwide cohort study

Research output: Contribution to journalJournal articleResearchpeer-review


  1. Influence and management of conflicts of interest in randomised clinical trials: qualitative interview study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Laparoscopic versus robot assisted repair of ventral hernia

    Research output: Contribution to journalEditorialResearchpeer-review

  3. Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevention of rhabdomyolysis-induced acute kidney injury - A DASAIM/DSIT clinical practice guideline

    Research output: Contribution to journalReviewResearchpeer-review

  2. Intracranial pressure during hemodialysis in patients with acute brain injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Lower short-term mortality in ICU patients on chronic dialysis than in those requiring acute dialysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Increased Intracranial Pressure during Hemodialysis in a Patient with Anoxic Brain Injury

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

OBJECTIVE: To investigate associations between pre-eclampsia and later risk of kidney disease.

DESIGN: Nationwide register based cohort study.

SETTING: Denmark.

POPULATION: All women with at least one pregnancy lasting at least 20 weeks between 1978 and 2015.

MAIN OUTCOME MEASURE: Hazard ratios comparing rates of kidney disease between women with and without a history of pre-eclampsia, stratified by gestational age at delivery and estimated using Cox regression.

RESULTS: The cohort consisted of 1 072 330 women followed for 19 994 470 person years (average 18.6 years/woman). Compared with women with no previous pre-eclampsia, those with a history of pre-eclampsia were more likely to develop chronic renal conditions: hazard ratio 3.93 (95% confidence interval 2.90 to 5.33, for early preterm pre-eclampsia (delivery <34 weeks); 2.81 (2.13 to 3.71) for late preterm pre-eclampsia (delivery 34-36 weeks); 2.27 (2.02 to 2.55) for term pre-eclampsia (delivery ≥37 weeks). In particular, strong associations were observed for chronic kidney disease, hypertensive kidney disease, and glomerular/proteinuric disease. Adjustment for cardiovascular disease and hypertension only partially attenuated the observed associations. Stratifying the analyses on time since pregnancy showed that associations between pre-eclampsia and chronic kidney disease and glomerular/proteinuric disease were much stronger within five years of the latest pregnancy (hazard ratio 6.11 (3.84 to 9.72) and 4.77 (3.88 to 5.86), respectively) than five years or longer after the latest pregnancy (2.06 (1.69 to 2.50) and 1.50 (1.19 to 1.88). By contrast, associations between pre-eclampsia and acute renal conditions were modest.

CONCLUSION: s Pre-eclampsia, particularly early preterm pre-eclampsia, was strongly associated with several chronic renal disorders later in life. More research is needed to determine which women are most likely to develop kidney disease after pre-eclampsia, what mechanisms underlie the association, and what clinical follow-up and interventions (and in what timeframe post-pregnancy) would be most appropriate and effective.

Original languageEnglish
Article number1516
Pages (from-to)l1516
Publication statusPublished - 29 Apr 2019

    Research areas

  • Adult, Cardiovascular Diseases/complications, Denmark/epidemiology, Female, Gestational Age, Humans, Hypertension/complications, Hypertension, Renal/complications, Kidney Diseases/diagnosis, Monitoring, Physiologic/standards, Postpartum Period, Pre-Eclampsia/diagnosis, Pregnancy, Risk Factors, Young Adult

ID: 58587367