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Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures

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Harvard

Nielsen, MS, Christensen, BJ, Schmidt, JB, Tækker, L, Holm, L, Lunn, S, Ritz, C, Wewer Albrechtsen, NJ, Holst, JJ, Schnurr, TM, Hansen, T, le Roux, CW, Lund, TB, Floyd, AK & Sjödin, A 2020, 'Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures', International journal of obesity (2005), vol. 44, no. 11, pp. 2291-2302. https://doi.org/10.1038/s41366-020-0576-9

APA

Nielsen, M. S., Christensen, B. J., Schmidt, J. B., Tækker, L., Holm, L., Lunn, S., Ritz, C., Wewer Albrechtsen, N. J., Holst, J. J., Schnurr, T. M., Hansen, T., le Roux, C. W., Lund, T. B., Floyd, A. K., & Sjödin, A. (2020). Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures. International journal of obesity (2005), 44(11), 2291-2302. https://doi.org/10.1038/s41366-020-0576-9

CBE

Nielsen MS, Christensen BJ, Schmidt JB, Tækker L, Holm L, Lunn S, Ritz C, Wewer Albrechtsen NJ, Holst JJ, Schnurr TM, Hansen T, le Roux CW, Lund TB, Floyd AK, Sjödin A. 2020. Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures. International journal of obesity (2005). 44(11):2291-2302. https://doi.org/10.1038/s41366-020-0576-9

MLA

Vancouver

Author

Nielsen, Mette S ; Christensen, Bodil Just ; Schmidt, Julie Berg ; Tækker, Louise ; Holm, Lotte ; Lunn, Susanne ; Ritz, Christian ; Wewer Albrechtsen, Nicolai J ; Holst, Jens Juul ; Schnurr, Theresia M ; Hansen, Torben ; le Roux, Carel W ; Lund, Thomas Bøker ; Floyd, Andrea Karen ; Sjödin, Anders. / Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures. In: International journal of obesity (2005). 2020 ; Vol. 44, No. 11. pp. 2291-2302.

Bibtex

@article{678aeeeda2bd46e89f4ba8f1c82f16c0,
title = "Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures",
abstract = "BACKGROUND: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.METHODS: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).RESULTS: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).CONCLUSIONS: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.",
author = "Nielsen, {Mette S} and Christensen, {Bodil Just} and Schmidt, {Julie Berg} and Louise T{\ae}kker and Lotte Holm and Susanne Lunn and Christian Ritz and {Wewer Albrechtsen}, {Nicolai J} and Holst, {Jens Juul} and Schnurr, {Theresia M} and Torben Hansen and {le Roux}, {Carel W} and Lund, {Thomas B{\o}ker} and Floyd, {Andrea Karen} and Anders Sj{\"o}din",
year = "2020",
month = nov,
doi = "10.1038/s41366-020-0576-9",
language = "English",
volume = "44",
pages = "2291--2302",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "11",

}

RIS

TY - JOUR

T1 - Predictors of weight loss after bariatric surgery-a cross-disciplinary approach combining physiological, social, and psychological measures

AU - Nielsen, Mette S

AU - Christensen, Bodil Just

AU - Schmidt, Julie Berg

AU - Tækker, Louise

AU - Holm, Lotte

AU - Lunn, Susanne

AU - Ritz, Christian

AU - Wewer Albrechtsen, Nicolai J

AU - Holst, Jens Juul

AU - Schnurr, Theresia M

AU - Hansen, Torben

AU - le Roux, Carel W

AU - Lund, Thomas Bøker

AU - Floyd, Andrea Karen

AU - Sjödin, Anders

PY - 2020/11

Y1 - 2020/11

N2 - BACKGROUND: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.METHODS: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).RESULTS: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).CONCLUSIONS: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.

AB - BACKGROUND: Bariatric surgery leads to a substantial weight loss (WL), however, a subset of patients undergoing surgery fails to achieve adequate WL. The reason for the individual variation in WL remains unexplained. Using an exploratory cross-disciplinary approach, we aimed to identify preoperative and early postoperative factors explaining the variation in WL after bariatric surgery.METHODS: Sixty-one subjects were recruited. Eighteen subjects did not receive surgery and three subjects dropped out, leaving a total sample of 40 subjects. Physiological, social, and psychological data were collected before and 6 months after surgery. All variables were analyzed in combination using a least absolute shrinkage and selection operator (LASSO) regression to explain the variation in WL 18 months after Roux-en-Y gastric bypass (n = 30) and sleeve gastrectomy (n = 10).RESULTS: Mean WL was 31% (range: 10-52%). The following preoperative factors predicted 59% of the variation in WL: type of surgery (14%), diabetes status (12%), economic resources (9%), sex (7%), binge eating disorder (7%), degree of depression (5%), household type (3%), and physical activity (1%). Including information on early responses after surgery increased the ability to predict WL to 78% and was explained by early WL (47%), changes in energy density of food consumed from a buffet meal (9%), changes in glicentin (5%), degree of depression (5%), sex (5%), type of surgery (2%), economic resources (2%), and changes in drive for thinness (1%).CONCLUSIONS: Using a cross-disciplinary approach, a substantial part of the individual variation in WL was explained by a combination of basic patient characteristics, psychological profile, and social conditions as well as physiological, psychological and behavioral responses to surgery. These results suggest that patient characteristics collected in a cross-disciplinary approach may help determine predictors for less successful WL after bariatric surgery. If verified in larger cohorts this may form the basis for individualized postoperative support to optimize WL outcome.

UR - http://www.scopus.com/inward/record.url?scp=85084129598&partnerID=8YFLogxK

U2 - 10.1038/s41366-020-0576-9

DO - 10.1038/s41366-020-0576-9

M3 - Journal article

C2 - 32327722

VL - 44

SP - 2291

EP - 2302

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 11

ER -

ID: 61271736