Predictors of adverse events after endoscopic ultrasound-guided through-The-needle biopsy of pancreatic cysts: A recursive partitioning analysis

Antonio Facciorusso, Bojan Kovacevic, Dennis Yang, Filipe Vilas-Boas, Belén Martínez-Moreno, Serena Stigliano, Gianenrico Rizzatti, Marco Sacco, Martha Arevalo-Mora, Leonardo Villarreal-Sanchez, Maria Cristina Conti Bellocchi, Laura Bernardoni, Armando Gabbrielli, Luca Barresi, Paraskevas Gkolfakis, Carlos Robles-Medranda, Claudio De Angelis, Alberto Larghi, Francesco Maria Di Matteo, José R. AparicioGuilherme Macedo, Peter V. Draganov, Peter Vilmann, Leandro Pecchia, Alessandro Repici, Stefano Francesco Crinò*

*Corresponding author for this work
47 Citations (Scopus)

Abstract

Background and study aims Endoscopic ultrasoundguided through-The-needle biopsy (TTNB) of pancreatic cystic lesions (PCLs) is associated with a non-negligible risk for adverse events (AEs). We aimed to identify the hierarchic interaction among independent predictors for TTNBrelated AEs and to generate a prognostic model using recursive partitioning analysis (RPA). Patients and methods Multicenter retrospective analysis of 506 patients with PCLs who underwent TTNB. RPA of predictors for AEs was performed and the model was validated by means of bootstrap resampling. Results Mean cysts size was 36.7mm. Most common diagnoses were intraductal papillary mucinous neoplasm (IPMN, 45 %), serous cystadenoma (18.8 %), and mucinous cystadenoma (12.8 %). Fifty-eight (11.5%) AEs were observed. At multivariate analysis, age (odds ratio [OR] 1.32, 1.09 2.14; p = 0.05), number of TTNB passes (OR from 2.17, 1.32 4.34 to OR 3.16, 2.03 6.34 with the increase of the number of passes), complete aspiration of the cyst (OR 0.56, 0.31 0.95; p = 0.02), and diagnosis of IPMN (OR 4.16, 2.27 7.69; p < 0.001) were found to be independent predictors of AEs, as confirmed by logistic regression and random forest analyses. RPA identified three risk classes: high-risk (IPMN sampled with multiple microforceps passes, 28% AEs rate), low-risk (1.4% AE rate, including patients < 64 years with other-Than-IPMN diagnosis sampled with ? 2 microforceps passes and with complete aspiration of the cyst) and middle-risk class (6.1% AEs rate, including the remaining patients). Conclusion TTNB should be selectively used in the evaluation of patients with IPMN. The present model could be applied during patient selection as to optimize the benefit/risk of TTNB.

Original languageEnglish
JournalEndoscopy
Volume54
Issue number12
Pages (from-to)1158-1168
Number of pages11
ISSN0013-726X
DOIs
Publication statusPublished - Dec 2022

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