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Predictive value of plasma hCG measured 14 days after Day-2 single embryo transfer

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INTRODUCTION: Prediction of pregnancy outcome after IVF is important for patients and clinicians. Early plasma hCG (p-hCG) levels are the best known predictor of pregnancy outcome, but no studies has been restricted to single embryo transfer (SET) of Day-2 embryos. The aim of the present study was to investigate the predictive value of p-hCG measured exactly 14 days after the most commonly used Day-2 SET on pregnancy, delivery and perinatal outcome.

MATERIALS AND METHODS: A retrospective analysis of prospectively collected data on 466 women who had p-hCG measured exactly 14 days after Day-2 SET during a randomized trial including 1050 unselected women (aged 18-40 years) undergoing their first IVF/ICSI treatment.

RESULTS: P-hCG predicted clinical pregnancy (AUC 0.953; 95% CI 0.915-0.992) significantly better than ongoing pregnancy (AUC 0.803, 95% CI; 0.717-0.890) and delivery (AUC 0.772, 95% CI; 0.691-0.854). Women with p-hCG levels in the lowest quartile had significantly lower clinical pregnancy, ongoing pregnancy, and delivery rates (p<0.001), whereas the pregnancy outcome and post-clinical pregnancy loss remained similar throughout the three highest p-hCG quartiles. The p-hCG level was neither related to birthweight nor gestational age at delivery.

CONCLUSIONS: Clinical pregnancy is significantly better predicted by p-hCG compared to ongoing pregnancy and delivery. Clinical pregnancy rates, ongoing pregnancy rates and delivery rates remained similar throughout the three highest p-hCG quartiles with no trend towards "the higher the better". This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume96
Issue number8
Pages (from-to)960-967
ISSN0001-6349
DOIs
Publication statusPublished - 1 Aug 2017

    Research areas

  • Journal Article

ID: 50179195