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Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD

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Hartjes, FJ, Vonk, JM, Faiz, A, Hiemstra, PS, Lapperre, TS, Kerstjens, HAM, Postma, DS, van den Berge, M & and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group 2018, 'Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD' Respirology (Carlton, Vic.), pp. 1023-1031. https://doi.org/10.1111/resp.13312

APA

Hartjes, F. J., Vonk, J. M., Faiz, A., Hiemstra, P. S., Lapperre, T. S., Kerstjens, H. A. M., ... and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group (2018). Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD. Respirology (Carlton, Vic.), 1023-1031. https://doi.org/10.1111/resp.13312

CBE

Hartjes FJ, Vonk JM, Faiz A, Hiemstra PS, Lapperre TS, Kerstjens HAM, Postma DS, van den Berge M, and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group. 2018. Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD. Respirology (Carlton, Vic.). 1023-1031. https://doi.org/10.1111/resp.13312

MLA

Vancouver

Author

Hartjes, Floor J ; Vonk, Judith M ; Faiz, Alen ; Hiemstra, Pieter S ; Lapperre, Thérèse S ; Kerstjens, Huib A M ; Postma, Dirkje S ; van den Berge, Maarten ; and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group. / Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD. In: Respirology (Carlton, Vic.). 2018 ; pp. 1023-1031.

Bibtex

@article{92b6493a6dde4d66b12ffddb52b92a17,
title = "Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD",
abstract = "BACKGROUND AND OBJECTIVE: Inflammation is present to a variable degree and composition in patients with COPD. This study investigates associations between both eosinophils and neutrophils in blood, sputum, airway wall biopsies and bronchoalveolar lavage (BAL) and their potential use as biomarkers for clinical response to inhaled corticosteroids (ICS).METHODS: In total, 114 steroid-na{\"i}ve COPD patients of the Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) study using ICS or placebo during 30-month follow-up were included. Cell counts in blood, sputum, biopsies and BAL were evaluated at baseline. In addition, at baseline, 6 and 30 months, forced expiratory flow in 1 s (FEV1 ), residual volume/total lung capacity (hyperinflation) and Clinical COPD Questionnaire were evaluated.RESULTS: Cross-sectional analyses at baseline showed that higher blood eosinophils were significantly associated with higher eosinophil counts in sputum, biopsies and BAL. However, blood neutrophils did not significantly correlate with neutrophil counts in the other compartments. Baseline eosinophils and neutrophils, in whichever compartment measured, did not predict longitudinal FEV1 changes. Higher baseline biopsy eosinophils were associated with an increase in symptoms during 6- and 30-month ICS treatment. In addition, higher biopsy neutrophils were associated with a more marked reduction in hyperinflation during 6-month ICS treatment compared with placebo.CONCLUSION: Our findings indicate that blood eosinophils reflect eosinophils in other compartments, in contrast to neutrophils, in ICS-na{\"i}ve COPD patients. Both baseline eosinophils and neutrophils do not predict ICS-induced lung function changes over a period of 6-30 months. The associations of biopsy eosinophils with worsening respiratory symptoms and biopsy neutrophils with improvement in hyperinflation during ICS treatment deserve further investigation.",
keywords = "Journal Article",
author = "Hartjes, {Floor J} and Vonk, {Judith M} and Alen Faiz and Hiemstra, {Pieter S} and Lapperre, {Th{\'e}r{\`e}se S} and Kerstjens, {Huib A M} and Postma, {Dirkje S} and {van den Berge}, Maarten and {and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group}",
note = "{\circledC} 2018 Asian Pacific Society of Respirology.",
year = "2018",
doi = "10.1111/resp.13312",
language = "English",
pages = "1023--1031",
journal = "Respirology",
issn = "1323-7799",
publisher = "Wiley-Blackwell Publishing Asia",

}

RIS

TY - JOUR

T1 - Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD

AU - Hartjes, Floor J

AU - Vonk, Judith M

AU - Faiz, Alen

AU - Hiemstra, Pieter S

AU - Lapperre, Thérèse S

AU - Kerstjens, Huib A M

AU - Postma, Dirkje S

AU - van den Berge, Maarten

AU - and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group

N1 - © 2018 Asian Pacific Society of Respirology.

PY - 2018

Y1 - 2018

N2 - BACKGROUND AND OBJECTIVE: Inflammation is present to a variable degree and composition in patients with COPD. This study investigates associations between both eosinophils and neutrophils in blood, sputum, airway wall biopsies and bronchoalveolar lavage (BAL) and their potential use as biomarkers for clinical response to inhaled corticosteroids (ICS).METHODS: In total, 114 steroid-naïve COPD patients of the Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) study using ICS or placebo during 30-month follow-up were included. Cell counts in blood, sputum, biopsies and BAL were evaluated at baseline. In addition, at baseline, 6 and 30 months, forced expiratory flow in 1 s (FEV1 ), residual volume/total lung capacity (hyperinflation) and Clinical COPD Questionnaire were evaluated.RESULTS: Cross-sectional analyses at baseline showed that higher blood eosinophils were significantly associated with higher eosinophil counts in sputum, biopsies and BAL. However, blood neutrophils did not significantly correlate with neutrophil counts in the other compartments. Baseline eosinophils and neutrophils, in whichever compartment measured, did not predict longitudinal FEV1 changes. Higher baseline biopsy eosinophils were associated with an increase in symptoms during 6- and 30-month ICS treatment. In addition, higher biopsy neutrophils were associated with a more marked reduction in hyperinflation during 6-month ICS treatment compared with placebo.CONCLUSION: Our findings indicate that blood eosinophils reflect eosinophils in other compartments, in contrast to neutrophils, in ICS-naïve COPD patients. Both baseline eosinophils and neutrophils do not predict ICS-induced lung function changes over a period of 6-30 months. The associations of biopsy eosinophils with worsening respiratory symptoms and biopsy neutrophils with improvement in hyperinflation during ICS treatment deserve further investigation.

AB - BACKGROUND AND OBJECTIVE: Inflammation is present to a variable degree and composition in patients with COPD. This study investigates associations between both eosinophils and neutrophils in blood, sputum, airway wall biopsies and bronchoalveolar lavage (BAL) and their potential use as biomarkers for clinical response to inhaled corticosteroids (ICS).METHODS: In total, 114 steroid-naïve COPD patients of the Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) study using ICS or placebo during 30-month follow-up were included. Cell counts in blood, sputum, biopsies and BAL were evaluated at baseline. In addition, at baseline, 6 and 30 months, forced expiratory flow in 1 s (FEV1 ), residual volume/total lung capacity (hyperinflation) and Clinical COPD Questionnaire were evaluated.RESULTS: Cross-sectional analyses at baseline showed that higher blood eosinophils were significantly associated with higher eosinophil counts in sputum, biopsies and BAL. However, blood neutrophils did not significantly correlate with neutrophil counts in the other compartments. Baseline eosinophils and neutrophils, in whichever compartment measured, did not predict longitudinal FEV1 changes. Higher baseline biopsy eosinophils were associated with an increase in symptoms during 6- and 30-month ICS treatment. In addition, higher biopsy neutrophils were associated with a more marked reduction in hyperinflation during 6-month ICS treatment compared with placebo.CONCLUSION: Our findings indicate that blood eosinophils reflect eosinophils in other compartments, in contrast to neutrophils, in ICS-naïve COPD patients. Both baseline eosinophils and neutrophils do not predict ICS-induced lung function changes over a period of 6-30 months. The associations of biopsy eosinophils with worsening respiratory symptoms and biopsy neutrophils with improvement in hyperinflation during ICS treatment deserve further investigation.

KW - Journal Article

U2 - 10.1111/resp.13312

DO - 10.1111/resp.13312

M3 - Journal article

SP - 1023

EP - 1031

JO - Respirology

JF - Respirology

SN - 1323-7799

ER -

ID: 53786097