Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Predictive value of control of COPD for risk of exacerbations: An international, prospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Increased risk of major adverse cardiac events following the onset of acute exacerbations of COPD

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Importance of oesophageal ultrasound in mediastinal staging of lung cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Novel assessment tool to detect breathing pattern disorder in patients with refractory asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Predictive value of control of COPD for risk of exacerbations: An international, prospective study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Floor J Hartjes
  • Judith M Vonk
  • Alen Faiz
  • Pieter S Hiemstra
  • Thérèse S Lapperre
  • Huib A M Kerstjens
  • Dirkje S Postma
  • Maarten van den Berge
  • and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group
View graph of relations

BACKGROUND AND OBJECTIVE: Inflammation is present to a variable degree and composition in patients with COPD. This study investigates associations between both eosinophils and neutrophils in blood, sputum, airway wall biopsies and bronchoalveolar lavage (BAL) and their potential use as biomarkers for clinical response to inhaled corticosteroids (ICS).

METHODS: In total, 114 steroid-naïve COPD patients of the Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) study using ICS or placebo during 30-month follow-up were included. Cell counts in blood, sputum, biopsies and BAL were evaluated at baseline. In addition, at baseline, 6 and 30 months, forced expiratory flow in 1 s (FEV1 ), residual volume/total lung capacity (hyperinflation) and Clinical COPD Questionnaire were evaluated.

RESULTS: Cross-sectional analyses at baseline showed that higher blood eosinophils were significantly associated with higher eosinophil counts in sputum, biopsies and BAL. However, blood neutrophils did not significantly correlate with neutrophil counts in the other compartments. Baseline eosinophils and neutrophils, in whichever compartment measured, did not predict longitudinal FEV1 changes. Higher baseline biopsy eosinophils were associated with an increase in symptoms during 6- and 30-month ICS treatment. In addition, higher biopsy neutrophils were associated with a more marked reduction in hyperinflation during 6-month ICS treatment compared with placebo.

CONCLUSION: Our findings indicate that blood eosinophils reflect eosinophils in other compartments, in contrast to neutrophils, in ICS-naïve COPD patients. Both baseline eosinophils and neutrophils do not predict ICS-induced lung function changes over a period of 6-30 months. The associations of biopsy eosinophils with worsening respiratory symptoms and biopsy neutrophils with improvement in hyperinflation during ICS treatment deserve further investigation.

Original languageEnglish
JournalRespirology (Carlton, Vic.)
Pages (from-to)1023-1031
Number of pages9
ISSN1323-7799
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 53786097