Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

Matej Orešič; Tuulia Hyötyläinen; Anna Kotronen; Peddinti Gopalacharyulu; Heli Nygren; Johanna Arola; Sandra Castillo; Ismo Mattila; Antti Hakkarainen; Ronald J H Borra; Miikka-Juhani Honka; An Verrijken; Sven Francque; Patricia Iozzo; Marja Leivonen; Nabil Jaser; Anne Juuti; Thorkild I A Sørensen; Pirjo Nuutila; Luc Van Gaal; Hannele Yki-Järvinen

doi:10.1007/s00125-013-2981-2

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

Matej Orešič
, Tuulia Hyötyläinen
, Anna Kotronen
, Peddinti Gopalacharyulu
, Heli Nygren
, Johanna Arola
, Sandra Castillo
, Ismo Mattila
, Antti Hakkarainen
, Ronald J H Borra
, Miikka-Juhani Honka
, An Verrijken
, Sven Francque
, Patricia Iozzo
, Marja Leivonen
, Nabil Jaser
, Anne Juuti
, Thorkild I A Sørensen
, Pirjo Nuutila
, Luc Van Gaal

Hannele Yki-Järvinen

155 Citations (Scopus)

Abstract

We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.

Original language	English
Journal	Diabetologia
Volume	56
Issue number	10
Pages (from-to)	2266-74
Number of pages	9
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-013-2981-2
Publication status	Published - Oct 2013

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Orešič, M., Hyötyläinen, T., Kotronen, A., Gopalacharyulu, P., Nygren, H., Arola, J., Castillo, S., Mattila, I., Hakkarainen, A., Borra, R. J. H., Honka, M.-J., Verrijken, A., Francque, S., Iozzo, P., Leivonen, M., Jaser, N., Juuti, A., Sørensen, T. I. A., Nuutila, P., ... Yki-Järvinen, H. (2013). Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. Diabetologia, 56(10), 2266-74. https://doi.org/10.1007/s00125-013-2981-2

Orešič, M, Hyötyläinen, T, Kotronen, A, Gopalacharyulu, P, Nygren, H, Arola, J, Castillo, S, Mattila, I, Hakkarainen, A, Borra, RJH, Honka, M-J, Verrijken, A, Francque, S, Iozzo, P, Leivonen, M, Jaser, N, Juuti, A, Sørensen, TIA, Nuutila, P, Van Gaal, L & Yki-Järvinen, H 2013, 'Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids', Diabetologia, vol. 56, no. 10, pp. 2266-74. https://doi.org/10.1007/s00125-013-2981-2

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title = "Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids",

abstract = "We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.",

author = "Matej Ore{\v s}i{\v c} and Tuulia Hy{\"o}tyl{\"a}inen and Anna Kotronen and Peddinti Gopalacharyulu and Heli Nygren and Johanna Arola and Sandra Castillo and Ismo Mattila and Antti Hakkarainen and Borra, \{Ronald J H\} and Miikka-Juhani Honka and An Verrijken and Sven Francque and Patricia Iozzo and Marja Leivonen and Nabil Jaser and Anne Juuti and S{\o}rensen, \{Thorkild I A\} and Pirjo Nuutila and \{Van Gaal\}, Luc and Hannele Yki-J{\"a}rvinen",

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doi = "10.1007/s00125-013-2981-2",

language = "English",

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AU - Orešič, Matej

AU - Hyötyläinen, Tuulia

AU - Kotronen, Anna

AU - Gopalacharyulu, Peddinti

AU - Nygren, Heli

AU - Arola, Johanna

AU - Castillo, Sandra

AU - Mattila, Ismo

AU - Hakkarainen, Antti

AU - Borra, Ronald J H

AU - Honka, Miikka-Juhani

AU - Verrijken, An

AU - Francque, Sven

AU - Iozzo, Patricia

AU - Leivonen, Marja

AU - Jaser, Nabil

AU - Juuti, Anne

AU - Sørensen, Thorkild I A

AU - Nuutila, Pirjo

AU - Van Gaal, Luc

AU - Yki-Järvinen, Hannele

PY - 2013/10

Y1 - 2013/10

N2 - We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.

AB - We examined whether analysis of lipids by ultra-performance liquid chromatography (UPLC) coupled to MS allows the development of a laboratory test for non-alcoholic fatty-liver disease (NAFLD), and how a lipid-profile biomarker compares with the prediction of NAFLD and liver-fat content based on routinely available clinical and laboratory data.

U2 - 10.1007/s00125-013-2981-2

DO - 10.1007/s00125-013-2981-2

M3 - Journal article

C2 - 23824212

SN - 0012-186X

VL - 56

SP - 2266

EP - 2274

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

Abstract

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