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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Prediction of birth weight small for gestational age with and without preeclampsia by angiogenic markers: an Odense Child Cohort study

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  • Lena Heidi Bækgaard Thorsen
  • Louise Bjørkholt Andersen
  • Anna Birukov
  • Sine Lykkedegn
  • Ralf Dechend
  • Jan Stener Jørgensen
  • Henrik Thybo Christesen
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Purpose: To investigate the predictive performance of placental growth factor (PlGF) and soluble FMS-like kinase 1 (sFlt-1) on birth weight and small for gestational age (SGA), in a large, population-based cohort.Methods: Women enrolled in the population-based, prospective Odense Child Cohort Study with early (GA < 20 weeks) and/or late (≥20 weeks) pregnancy blood samples (n = 1937) were included. The association between log-transformed values of the biomarkers and birth weight Z-score was studied using multivariate regression models. The prediction of SGA overall, and in women developing preeclampsia, by biomarkers was evaluated using receiver operating characteristic analyses.Results: No substantial associations between early pregnancy biomarkers and SGA were seen. PlGF measured in late pregnancy demonstrated the strongest association with birth weight Z-score (adjusted β-coefficient = 0.43 [95%CI = 0.35; 0.50]). The area under curve (AUC) for predicting SGA was higher for sFlt-1/PlGF compared to sFlt-1 (0.74 versus 0.63, p = .006) and reached excellent prediction for SGA after preeclampsia (AUC 0.94). Optimal sFlt-1/PlGF ratio cut-offs had higher negative predictive value (NPV) and positive predictive value (PPV) for SGA (cut-off > 5.0; NPV = 99.1%, PPV = 5.4%) compared to each marker individually.Conclusion: The sFlt-1/PlGF ratio is a potential predictor of SGA in population-based screening, particularly when preeclampsia is also present.

Original languageEnglish
JournalThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Volume33
Issue number8
Pages (from-to)1377-1384
Number of pages8
ISSN1476-7058
DOIs
Publication statusPublished - Apr 2020

    Research areas

  • Area Under Curve, Biomarkers/blood, Birth Weight/genetics, Female, Gestational Age, Humans, Infant, Small for Gestational Age, Placenta Growth Factor/blood, Pre-Eclampsia/epidemiology, Pregnancy, Prospective Studies, Vascular Endothelial Growth Factor Receptor-1/blood

ID: 61827885