Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [ 11C]Cimbi-36

Anders Ettrup; Søren Holm; Martin Hansen; Muhammad Wasim; Martin Andreas Santini; Mikael Palner; Jacob Madsen; Claus Svarer; Jesper Langgaard Kristensen; Gitte Moos Knudsen

doi:10.1007/s11307-012-0609-4

Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [ 11C]Cimbi-36

Anders Ettrup, Søren Holm, Martin Hansen, Muhammad Wasim, Martin Andreas Santini, Mikael Palner, Jacob Madsen, Claus Svarer, Jesper Langgaard Kristensen, Gitte Moos Knudsen

46 Citations (Scopus)

Abstract

[11C]Cimbi-36 was recently developed as an agonist radioligand for brain imaging of serotonin 2A receptors (5-HT2A) with positron emission tomography (PET). This may be used to quantify the high-affinity state of 5-HT2A receptors and may have the potential to quantify changes in cerebral 5-HT levels in vivo. We here investigated safety aspects related to clinical use of [11C]Cimbi-36, including radiation dosimetry and in vivo pharmacology.

Original language	English
Journal	Molecular Imaging and Biology
Volume	15
Issue number	4
Pages (from-to)	376-83
Number of pages	8
ISSN	1536-1632
DOIs	https://doi.org/10.1007/s11307-012-0609-4
Publication status	Published - Aug 2013

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AU - Ettrup, Anders

AU - Holm, Søren

AU - Hansen, Martin

AU - Wasim, Muhammad

AU - Santini, Martin Andreas

AU - Palner, Mikael

AU - Madsen, Jacob

AU - Svarer, Claus

AU - Kristensen, Jesper Langgaard

AU - Knudsen, Gitte Moos

PY - 2013/8

Y1 - 2013/8

N2 - [11C]Cimbi-36 was recently developed as an agonist radioligand for brain imaging of serotonin 2A receptors (5-HT2A) with positron emission tomography (PET). This may be used to quantify the high-affinity state of 5-HT2A receptors and may have the potential to quantify changes in cerebral 5-HT levels in vivo. We here investigated safety aspects related to clinical use of [11C]Cimbi-36, including radiation dosimetry and in vivo pharmacology.

AB - [11C]Cimbi-36 was recently developed as an agonist radioligand for brain imaging of serotonin 2A receptors (5-HT2A) with positron emission tomography (PET). This may be used to quantify the high-affinity state of 5-HT2A receptors and may have the potential to quantify changes in cerebral 5-HT levels in vivo. We here investigated safety aspects related to clinical use of [11C]Cimbi-36, including radiation dosimetry and in vivo pharmacology.

UR - https://www.scopus.com/pages/publications/84880326182

U2 - 10.1007/s11307-012-0609-4

DO - 10.1007/s11307-012-0609-4

M3 - Journal article

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SN - 1536-1632

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EP - 383

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

IS - 4

ER -

Preclinical safety assessment of the 5-HT2A receptor agonist PET radioligand [ 11C]Cimbi-36

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