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Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

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  • Mohamed Abdulkadir
  • Jay A Tischfield
  • Robert A King
  • Thomas V Fernandez
  • Lawrence W Brown
  • Keun-Ah Cheon
  • Barbara J Coffey
  • Sebastian F T M de Bruijn
  • Lonneke Elzerman
  • Blanca Garcia-Delgar
  • Donald L Gilbert
  • Dorothy E Grice
  • Julie Hagstrøm
  • Tammy Hedderly
  • Isobel Heyman
  • Hyun Ju Hong
  • Chaim Huyser
  • Laura Ibanez-Gomez
  • Young Key Kim
  • Young-Shin Kim
  • Yun-Joo Koh
  • Sodahm Kook
  • Samuel Kuperman
  • Andreas Lamerz
  • Bennett Leventhal
  • Andrea G Ludolph
  • Marcos Madruga-Garrido
  • Athanasios Maras
  • Marieke D Messchendorp
  • Pablo Mir
  • Astrid Morer
  • Alexander Münchau
  • Tara L Murphy
  • Thaïra J C Openneer
  • Kerstin J Plessen
  • Judith J G Rath
  • Veit Roessner
  • Odette Fründt
  • Eun-Young Shin
  • Deborah A Sival
  • Dong-Ho Song
  • Jungeun Song
  • Anne-Marie Stolte
  • Jennifer Tübing
  • Els van den Ban
  • Frank Visscher
  • Sina Wanderer
  • Martin Woods
  • Samuel H Zinner
  • Matthew W State
  • Gary A Heiman
  • Pieter J Hoekstra
  • Andrea Dietrich
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Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Original languageEnglish
JournalJournal of Psychiatric Research
Volume82
Pages (from-to)126-135
Number of pages10
ISSN0022-3956
DOIs
Publication statusPublished - Nov 2016

ID: 48333226