Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

Matthew T Roe; Paul W Armstrong; Keith A A Fox; Harvey D White; Dorairaj Prabhakaran; Shaun G Goodman; Jan H Cornel; Deepak L Bhatt; Peter Clemmensen; Felipe Martinez; Diego Ardissino; Jose C Nicolau; William E Boden; Paul A Gurbel; Witold Ruzyllo; Anthony J Dalby; Darren K McGuire; Jose L Leiva-Pons; Alexander Parkhomenko; Shmuel Gottlieb; Gracita O Topacio; Christian Hamm; Gregory Pavlides; Assen R Goudev; Ali Oto; Chuen-Den Tseng; Bela Merkely; Vladimir Gasparovic; Ramon Corbalan; Mircea Cinteză; R Craig McLendon; Kenneth J Winters; Eileen B Brown; Yuliya Lokhnygina; Philip E Aylward; Kurt Huber; Judith S Hochman; E Magnus Ohman; TRILOGY ACS Investigators

doi:10.1056/NEJMoa1205512

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

Matthew T Roe, Paul W Armstrong, Keith A A Fox, Harvey D White, Dorairaj Prabhakaran, Shaun G Goodman, Jan H Cornel, Deepak L Bhatt, Peter Clemmensen, Felipe Martinez, Diego Ardissino, Jose C Nicolau, William E Boden, Paul A Gurbel, Witold Ruzyllo, Anthony J Dalby, Darren K McGuire, Jose L Leiva-Pons, Alexander Parkhomenko, Shmuel GottliebGracita O Topacio, Christian Hamm, Gregory Pavlides, Assen R Goudev, Ali Oto, Chuen-Den Tseng, Bela Merkely, Vladimir Gasparovic, Ramon Corbalan, Mircea Cinteză, R Craig McLendon, Kenneth J Winters, Eileen B Brown, Yuliya Lokhnygina, Philip E Aylward, Kurt Huber, Judith S Hochman, E Magnus Ohman, TRILOGY ACS Investigators

788 Citations (Scopus)

Abstract

The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated.

Original language	English
Journal	New England Journal of Medicine
Volume	367
Issue number	14
Pages (from-to)	1297-309
Number of pages	13
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1205512
Publication status	Published - 2012

Keywords

Acute Coronary Syndrome
Aged
Angina, Unstable
Aspirin
Cardiovascular Diseases
Double-Blind Method
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Myocardial Infarction
Piperazines
Platelet Aggregation Inhibitors
Purinergic P2 Receptor Antagonists
Stroke
Thiophenes
Ticlopidine

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Roe, M. T., Armstrong, P. W., Fox, K. A. A., White, H. D., Prabhakaran, D., Goodman, S. G., Cornel, J. H., Bhatt, D. L., Clemmensen, P., Martinez, F., Ardissino, D., Nicolau, J. C., Boden, W. E., Gurbel, P. A., Ruzyllo, W., Dalby, A. J., McGuire, D. K., Leiva-Pons, J. L., Parkhomenko, A., ... TRILOGY ACS Investigators (2012). Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. New England Journal of Medicine, 367(14), 1297-309. https://doi.org/10.1056/NEJMoa1205512

Roe, MT, Armstrong, PW, Fox, KAA, White, HD, Prabhakaran, D, Goodman, SG, Cornel, JH, Bhatt, DL, Clemmensen, P, Martinez, F, Ardissino, D, Nicolau, JC, Boden, WE, Gurbel, PA, Ruzyllo, W, Dalby, AJ, McGuire, DK, Leiva-Pons, JL, Parkhomenko, A, Gottlieb, S, Topacio, GO, Hamm, C, Pavlides, G, Goudev, AR, Oto, A, Tseng, C-D, Merkely, B, Gasparovic, V, Corbalan, R, Cinteză, M, McLendon, RC, Winters, KJ, Brown, EB, Lokhnygina, Y, Aylward, PE, Huber, K, Hochman, JS, Ohman, EM & TRILOGY ACS Investigators 2012, 'Prasugrel versus clopidogrel for acute coronary syndromes without revascularization', New England Journal of Medicine, vol. 367, no. 14, pp. 1297-309. https://doi.org/10.1056/NEJMoa1205512

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title = "Prasugrel versus clopidogrel for acute coronary syndromes without revascularization",

abstract = "The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated.",

keywords = "Acute Coronary Syndrome, Aged, Angina, Unstable, Aspirin, Cardiovascular Diseases, Double-Blind Method, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Myocardial Infarction, Piperazines, Platelet Aggregation Inhibitors, Purinergic P2 Receptor Antagonists, Stroke, Thiophenes, Ticlopidine",

author = "Roe, \{Matthew T\} and Armstrong, \{Paul W\} and Fox, \{Keith A A\} and White, \{Harvey D\} and Dorairaj Prabhakaran and Goodman, \{Shaun G\} and Cornel, \{Jan H\} and Bhatt, \{Deepak L\} and Peter Clemmensen and Felipe Martinez and Diego Ardissino and Nicolau, \{Jose C\} and Boden, \{William E\} and Gurbel, \{Paul A\} and Witold Ruzyllo and Dalby, \{Anthony J\} and McGuire, \{Darren K\} and Leiva-Pons, \{Jose L\} and Alexander Parkhomenko and Shmuel Gottlieb and Topacio, \{Gracita O\} and Christian Hamm and Gregory Pavlides and Goudev, \{Assen R\} and Ali Oto and Chuen-Den Tseng and Bela Merkely and Vladimir Gasparovic and Ramon Corbalan and Mircea Cintez{\u a} and McLendon, \{R Craig\} and Winters, \{Kenneth J\} and Brown, \{Eileen B\} and Yuliya Lokhnygina and Aylward, \{Philip E\} and Kurt Huber and Hochman, \{Judith S\} and Ohman, \{E Magnus\} and \{TRILOGY ACS Investigators\}",

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volume = "367",

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AU - Roe, Matthew T

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AU - White, Harvey D

AU - Prabhakaran, Dorairaj

AU - Goodman, Shaun G

AU - Cornel, Jan H

AU - Bhatt, Deepak L

AU - Clemmensen, Peter

AU - Martinez, Felipe

AU - Ardissino, Diego

AU - Nicolau, Jose C

AU - Boden, William E

AU - Gurbel, Paul A

AU - Ruzyllo, Witold

AU - Dalby, Anthony J

AU - McGuire, Darren K

AU - Leiva-Pons, Jose L

AU - Parkhomenko, Alexander

AU - Gottlieb, Shmuel

AU - Topacio, Gracita O

AU - Hamm, Christian

AU - Pavlides, Gregory

AU - Goudev, Assen R

AU - Oto, Ali

AU - Tseng, Chuen-Den

AU - Merkely, Bela

AU - Gasparovic, Vladimir

AU - Corbalan, Ramon

AU - Cinteză, Mircea

AU - McLendon, R Craig

AU - Winters, Kenneth J

AU - Brown, Eileen B

AU - Lokhnygina, Yuliya

AU - Aylward, Philip E

AU - Huber, Kurt

AU - Hochman, Judith S

AU - Ohman, E Magnus

AU - TRILOGY ACS Investigators

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N2 - The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated.

AB - The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated.

KW - Acute Coronary Syndrome

KW - Aged

KW - Angina, Unstable

KW - Aspirin

KW - Cardiovascular Diseases

KW - Double-Blind Method

KW - Drug Therapy, Combination

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Piperazines

KW - Platelet Aggregation Inhibitors

KW - Purinergic P2 Receptor Antagonists

KW - Stroke

KW - Thiophenes

KW - Ticlopidine

UR - https://www.scopus.com/pages/publications/84867177857

U2 - 10.1056/NEJMoa1205512

DO - 10.1056/NEJMoa1205512

M3 - Journal article

C2 - 22920930

SN - 0028-4793

VL - 367

SP - 1297

EP - 1309

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 14

ER -

Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

Abstract

Keywords

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