Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

Mirabella Zhao; Mads Damsgaard Wewer; Jacob Tveiten Bjerrum; Casper Steenholdt; Frank Schiødt; Kent Haderslev; Marianne Kiszka-Kanowitz; Pia Munkholm; Jakob Seidelin; Johan Burisch

Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

Translated title of the contribution: Practical guide to the use of thiopurinesin patients with inflammatory bowel diseases

Mirabella Zhao, Mads Damsgaard Wewer, Jacob Tveiten Bjerrum, Casper Steenholdt, Frank Schiødt, Kent Haderslev, Marianne Kiszka-Kanowitz, Pia Munkholm, Jakob Seidelin, Johan Burisch^*

^*Corresponding author for this work

Abstract

Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.

Translated title of the contribution	Practical guide to the use of thiopurinesin patients with inflammatory bowel diseases
Original language	Danish
Article number	V09210706
Journal	Ugeskrift for Laeger
Volume	184
Issue number	11
Pages (from-to)	1-9
Number of pages	9
ISSN	0041-5782
Publication status	Published - 14 Mar 2022

Access to Document

https://ugeskriftet.dk/files/scientific_article_files/2022-03/v09210706_web.pdf

Cite this

Zhao, M., Wewer, M. D., Bjerrum, J. T., Steenholdt, C., Schiødt, F., Haderslev, K., Kiszka-Kanowitz, M., Munkholm, P., Seidelin, J., & Burisch, J. (2022). Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme. Ugeskrift for Laeger, 184(11), 1-9. Article V09210706. https://ugeskriftet.dk/files/scientific_article_files/2022-03/v09210706_web.pdf

Zhao, M, Wewer, MD, Bjerrum, JT, Steenholdt, C , Schiødt, F , Haderslev, K , Kiszka-Kanowitz, M , Munkholm, P , Seidelin, J & Burisch, J 2022, 'Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme', Ugeskrift for Laeger, vol. 184, no. 11, V09210706, pp. 1-9. <https://ugeskriftet.dk/files/scientific_article_files/2022-03/v09210706_web.pdf>

@article{0527b243b21b443ab8e7c8b454625bec,

title = "Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme",

abstract = "Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.",

keywords = "Humans, Immunologic Factors, Inflammatory Bowel Diseases/drug therapy, Mercaptopurine/adverse effects",

author = "Mirabella Zhao and Wewer, {Mads Damsgaard} and Bjerrum, {Jacob Tveiten} and Casper Steenholdt and Frank Schi{\o}dt and Kent Haderslev and Marianne Kiszka-Kanowitz and Pia Munkholm and Jakob Seidelin and Johan Burisch",

year = "2022",

month = mar,

day = "14",

language = "Dansk",

volume = "184",

pages = "1--9",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "11",

}

TY - JOUR

T1 - Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

AU - Zhao, Mirabella

AU - Wewer, Mads Damsgaard

AU - Bjerrum, Jacob Tveiten

AU - Steenholdt, Casper

AU - Schiødt, Frank

AU - Haderslev, Kent

AU - Kiszka-Kanowitz, Marianne

AU - Munkholm, Pia

AU - Seidelin, Jakob

AU - Burisch, Johan

PY - 2022/3/14

Y1 - 2022/3/14

N2 - Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.

AB - Despite the increasing availability of biological treatment in recent years, thiopurines remain an important treatment option in patients with inflammatory bowel diseases (IBD) both as monotherapy and in combination therapy with biologicals. Pre-treatment screening of thiopurine-methyltransferase activity and monitoring of thiopurine metabolites during treatment are essential to optimize the effectiveness and safety of thiopurines. This review provides an evidence-based practical guide to prescribing and monitoring thiopurines in patients with IBD.

KW - Humans

KW - Immunologic Factors

KW - Inflammatory Bowel Diseases/drug therapy

KW - Mercaptopurine/adverse effects

M3 - Review

C2 - 35315759

SN - 0041-5782

VL - 184

SP - 1

EP - 9

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 11

M1 - V09210706

ER -

Praktisk anvendelse af thiopuriner hos patienter med kronisk inflammatoriske tarmsygdomme

Abstract

Access to Document

Fingerprint

Cite this