Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers

Sini Takala; Kristoffer Lassen; Kjetil Søreide; Ernesto Sparrelid; Jon-Helge Angelsen; Erling A Bringeland; Malin S Eilard; Oskar Hemmingsson; Bengt Isaksson; Heikki Karjula; Jukka-Pekka Lammi; Peter N Larsen; Maija Lavonius; Gert Lindell; Frank V Mortensen; Kim Mortensen; Arno Nordin; Torsten Pless; Per Sandström; Oddvar Sandvik; Yrjö Vaalavuo; Christina Villard; Ville Sallinen

doi:10.1177/14574969231181228

Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers

Sini Takala, Kristoffer Lassen, Kjetil Søreide, Ernesto Sparrelid, Jon-Helge Angelsen, Erling A Bringeland, Malin S Eilard, Oskar Hemmingsson, Bengt Isaksson, Heikki Karjula, Jukka-Pekka Lammi, Peter N Larsen, Maija Lavonius, Gert Lindell, Frank V Mortensen, Kim Mortensen, Arno Nordin, Torsten Pless, Per Sandström, Oddvar SandvikYrjö Vaalavuo, Christina Villard, Ville Sallinen

5 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies.

METHODS: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals providing curative-intent surgery for GBC in Sweden, Norway, Denmark, and Finland.

RESULTS: In all Nordic countries except Sweden, neoadjuvant/downstaging chemotherapy was used in GBC patients. In T1b and T2, majority of the centers (15-18/19) performed extended cholecystectomy. In T3, majority of the centers (13/19) performed cholecystectomy with resection of segments 4b and 5. In T4, majority of the centers (12-14/19) chose palliative/oncological care. The centers in Sweden extended lymphadenectomy beyond the hepatoduodenal ligament, whereas all other Nordic centers usually limited lymphadenectomy to the hepatoduodenal ligament. All Nordic centers except those in Norway used adjuvant chemotherapy routinely for GBC. There were no major differences between the Nordic centers in diagnostics and follow-up.

CONCLUSIONS: The surgical and oncological treatment strategies of GBC vary considerably between the Nordic centers and countries.

Original language	English
Journal	Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society
Volume	112
Issue number	3
Pages (from-to)	147-156
Number of pages	10
ISSN	1457-4969
DOIs	https://doi.org/10.1177/14574969231181228
Publication status	Published - Sept 2023

Keywords

Cholecystectomy
Cross-Sectional Studies
Gallbladder Neoplasms/diagnosis
Humans
Lymph Node Excision
Neoadjuvant Therapy
Neoplasm Staging
Scandinavian and Nordic Countries
biliary tract
resectability
Survey
neoplasm
MDT

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10.1177/14574969231181228

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Takala, S., Lassen, K., Søreide, K., Sparrelid, E., Angelsen, J.-H., Bringeland, E. A., Eilard, M. S., Hemmingsson, O., Isaksson, B., Karjula, H., Lammi, J.-P., Larsen, P. N., Lavonius, M., Lindell, G., Mortensen, F. V., Mortensen, K., Nordin, A., Pless, T., Sandström, P., ... Sallinen, V. (2023). Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 112(3), 147-156. https://doi.org/10.1177/14574969231181228

Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers. / Takala, Sini; Lassen, Kristoffer; Søreide, Kjetil et al.
In: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, Vol. 112, No. 3, 09.2023, p. 147-156.

Research output: Contribution to journal › Journal article › Research › peer-review

Takala, S, Lassen, K, Søreide, K, Sparrelid, E, Angelsen, J-H, Bringeland, EA, Eilard, MS, Hemmingsson, O, Isaksson, B, Karjula, H, Lammi, J-P, Larsen, PN, Lavonius, M, Lindell, G, Mortensen, FV, Mortensen, K, Nordin, A, Pless, T, Sandström, P, Sandvik, O, Vaalavuo, Y, Villard, C & Sallinen, V 2023, 'Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers', Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, vol. 112, no. 3, pp. 147-156. https://doi.org/10.1177/14574969231181228

Takala S, Lassen K, Søreide K, Sparrelid E, Angelsen JH, Bringeland EA et al. Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society. 2023 Sept;112(3):147-156. doi: 10.1177/14574969231181228

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title = "Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers",

abstract = "BACKGROUND AND OBJECTIVE: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies.METHODS: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals providing curative-intent surgery for GBC in Sweden, Norway, Denmark, and Finland.RESULTS: In all Nordic countries except Sweden, neoadjuvant/downstaging chemotherapy was used in GBC patients. In T1b and T2, majority of the centers (15-18/19) performed extended cholecystectomy. In T3, majority of the centers (13/19) performed cholecystectomy with resection of segments 4b and 5. In T4, majority of the centers (12-14/19) chose palliative/oncological care. The centers in Sweden extended lymphadenectomy beyond the hepatoduodenal ligament, whereas all other Nordic centers usually limited lymphadenectomy to the hepatoduodenal ligament. All Nordic centers except those in Norway used adjuvant chemotherapy routinely for GBC. There were no major differences between the Nordic centers in diagnostics and follow-up.CONCLUSIONS: The surgical and oncological treatment strategies of GBC vary considerably between the Nordic centers and countries.",

keywords = "Cholecystectomy, Cross-Sectional Studies, Gallbladder Neoplasms/diagnosis, Humans, Lymph Node Excision, Neoadjuvant Therapy, Neoplasm Staging, Scandinavian and Nordic Countries, biliary tract, resectability, Survey, neoplasm, MDT",

author = "Sini Takala and Kristoffer Lassen and Kjetil S{\o}reide and Ernesto Sparrelid and Jon-Helge Angelsen and Bringeland, \{Erling A\} and Eilard, \{Malin S\} and Oskar Hemmingsson and Bengt Isaksson and Heikki Karjula and Jukka-Pekka Lammi and Larsen, \{Peter N\} and Maija Lavonius and Gert Lindell and Mortensen, \{Frank V\} and Kim Mortensen and Arno Nordin and Torsten Pless and Per Sandstr{\"o}m and Oddvar Sandvik and Yrj{\"o} Vaalavuo and Christina Villard and Ville Sallinen",

year = "2023",

month = sep,

doi = "10.1177/14574969231181228",

language = "English",

volume = "112",

pages = "147--156",

journal = "Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society",

issn = "1457-4969",

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TY - JOUR

T1 - Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers

AU - Takala, Sini

AU - Lassen, Kristoffer

AU - Søreide, Kjetil

AU - Sparrelid, Ernesto

AU - Angelsen, Jon-Helge

AU - Bringeland, Erling A

AU - Eilard, Malin S

AU - Hemmingsson, Oskar

AU - Isaksson, Bengt

AU - Karjula, Heikki

AU - Lammi, Jukka-Pekka

AU - Larsen, Peter N

AU - Lavonius, Maija

AU - Lindell, Gert

AU - Mortensen, Frank V

AU - Mortensen, Kim

AU - Nordin, Arno

AU - Pless, Torsten

AU - Sandström, Per

AU - Sandvik, Oddvar

AU - Vaalavuo, Yrjö

AU - Villard, Christina

AU - Sallinen, Ville

PY - 2023/9

Y1 - 2023/9

N2 - BACKGROUND AND OBJECTIVE: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies.METHODS: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals providing curative-intent surgery for GBC in Sweden, Norway, Denmark, and Finland.RESULTS: In all Nordic countries except Sweden, neoadjuvant/downstaging chemotherapy was used in GBC patients. In T1b and T2, majority of the centers (15-18/19) performed extended cholecystectomy. In T3, majority of the centers (13/19) performed cholecystectomy with resection of segments 4b and 5. In T4, majority of the centers (12-14/19) chose palliative/oncological care. The centers in Sweden extended lymphadenectomy beyond the hepatoduodenal ligament, whereas all other Nordic centers usually limited lymphadenectomy to the hepatoduodenal ligament. All Nordic centers except those in Norway used adjuvant chemotherapy routinely for GBC. There were no major differences between the Nordic centers in diagnostics and follow-up.CONCLUSIONS: The surgical and oncological treatment strategies of GBC vary considerably between the Nordic centers and countries.

AB - BACKGROUND AND OBJECTIVE: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies.METHODS: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals providing curative-intent surgery for GBC in Sweden, Norway, Denmark, and Finland.RESULTS: In all Nordic countries except Sweden, neoadjuvant/downstaging chemotherapy was used in GBC patients. In T1b and T2, majority of the centers (15-18/19) performed extended cholecystectomy. In T3, majority of the centers (13/19) performed cholecystectomy with resection of segments 4b and 5. In T4, majority of the centers (12-14/19) chose palliative/oncological care. The centers in Sweden extended lymphadenectomy beyond the hepatoduodenal ligament, whereas all other Nordic centers usually limited lymphadenectomy to the hepatoduodenal ligament. All Nordic centers except those in Norway used adjuvant chemotherapy routinely for GBC. There were no major differences between the Nordic centers in diagnostics and follow-up.CONCLUSIONS: The surgical and oncological treatment strategies of GBC vary considerably between the Nordic centers and countries.

KW - Cholecystectomy

KW - Cross-Sectional Studies

KW - Gallbladder Neoplasms/diagnosis

KW - Humans

KW - Lymph Node Excision

KW - Neoadjuvant Therapy

KW - Neoplasm Staging

KW - Scandinavian and Nordic Countries

KW - biliary tract

KW - resectability

KW - Survey

KW - neoplasm

KW - MDT

UR - https://www.scopus.com/pages/publications/85164399012

U2 - 10.1177/14574969231181228

DO - 10.1177/14574969231181228

M3 - Journal article

C2 - 37377127

SN - 1457-4969

VL - 112

SP - 147

EP - 156

JO - Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

JF - Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

IS - 3

ER -

Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers

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Keywords

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