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PPARs and the development of Type 1 Diabetes

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  1. Antibiotic treatment during early childhood and risk of type 1 diabetes in children: A national birth cohort study

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  2. Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment

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  3. Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice

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  4. L-serine: a neglected amino acid with a potential therapeutic role in diabetes

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  5. Oral LPS Dosing Induces Local Immunological Changes in the Pancreatic Lymph Nodes in Mice

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Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.

Original languageEnglish
Article number6198628
JournalPPAR Research
Volume2020
Pages (from-to)6198628
DOIs
Publication statusPublished - 2020

Bibliographical note

Copyright © 2020 Laurits J. Holm et al.

ID: 59203949