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Power estimations for non-primary outcomes in randomised clinical trials

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OBJECTIVE AND METHODS: It is rare that trialists report power estimations of non-primary outcomes. In the present article, we will describe how to define a valid hierarchy of outcomes in a randomised clinical trial, to limit problems with Type I and Type II errors, using considerations on the clinical relevance of the outcomes and power estimations.

CONCLUSION: Power estimations of non-primary outcomes may guide trialists in classifying non-primary outcomes as secondary or exploratory. The power estimations are simple and if they are used systematically, more appropriate outcome hierarchies can be defined, and trial results will become more interpretable.

Original languageEnglish
JournalBMJ Open
Volume9
Issue number6
Pages (from-to)e027092
ISSN2044-6055
DOIs
Publication statusPublished - 6 Jun 2019

ID: 57347345