Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Post-traumatic headache: epidemiology and pathophysiological insights

Research output: Contribution to journalReviewResearchpeer-review

  1. MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice

    Research output: Contribution to journalReviewResearchpeer-review

  2. Calcitonin gene-related peptide - beyond migraine prophylaxis

    Research output: Contribution to journalComment/debateResearchpeer-review

  3. Ageing as a risk factor for neurodegenerative disease

    Research output: Contribution to journalReviewResearchpeer-review

  4. Does inflammation have a role in migraine?

    Research output: Contribution to journalReviewResearchpeer-review

  5. CGRP as the target of new migraine therapies - successful translation from bench to clinic

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one of the most common sequelae of mild traumatic brain injury, also known as concussion. Considerable overlap exists between PTH and common primary headache disorders. The most common PTH phenotypes are migraine-like headache and tension-type-like headache. A better understanding of the pathophysiological similarities and differences between primary headache disorders and PTH could uncover unique treatment targets for PTH. Although possible underlying mechanisms of PTH have been elucidated, a substantial void remains in our understanding, and further research is needed. In this Review, we describe the evidence from animal and human studies that indicates involvement of several potential mechanisms in the development and persistence of PTH. These mechanisms include impaired descending modulation, neurometabolic changes, neuroinflammation and activation of the trigeminal sensory system. Furthermore, we outline future research directions to establish biomarkers involved in progression from acute to persistent PTH, and we identify potential drug targets to prevent and treat persistent PTH.

Original languageEnglish
JournalNature reviews. Neurology
Issue number10
Pages (from-to)607-617
Number of pages11
Publication statusPublished - Oct 2019

ID: 58653435