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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update

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  • Ana Elena Rodríguez-Rodríguez
  • Esteban Porrini
  • Mads Hornum
  • Javier Donate-Correa
  • Raúl Morales-Febles
  • Simran Khemlani Ramchand
  • María Xixiang Molina Lima
  • Armando Torres
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Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.

Original languageEnglish
JournalNephron
Volume145
Issue number4
Pages (from-to)317-329
Number of pages13
ISSN0028-2766
DOIs
Publication statusPublished - 2021

Bibliographical note

© 2021 S. Karger AG, Basel.

    Research areas

  • Diabetes Mellitus/etiology, Humans, Insulin Resistance, Kidney Transplantation, Prediabetic State/etiology, Transplant Recipients

ID: 70624346