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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report

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  1. The renal extraction and the natriuretic action of GLP-1 in humans depend on interaction with the GLP-1 receptor

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Counterregulatory responses to postprandial hypoglycemia after Roux-en-Y gastric bypass

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  3. Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

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Objective: To examine after gastric bypass the effect of peroral vs. gastroduodenal feeding on glucose metabolism. Research Design and Methods: A type 2 diabetic patient was examined on two consecutive days 5 weeks after gastric bypass. A standard liquid meal was given, on the first day into the bypassed gastric remnant and on the second day perorally. Plasma glucose, insulin, C peptide, glucagon, incretin hormones, peptide YY and free fatty acids were measured. Results: Peroral feeding reduced 2-h-postprandial plasma glucose (7.8 vs. 11.1 mM) and incremental-area-under-the-glucose-curve (0.33 vs. 0.49 mMxmin) compared with gastroduodenal feeding . beta-cell function (iAUC(Cpeptide/Glu)) was more than 2-fold improved during peroral feeding and the GLP-1 response increased nearly 5-fold. Conclustions: Improvement in postprandial glucose metabolism after gastric bypass is an immediate and direct consequence of the gastrointestinal rearrangement, associated with exaggerated GLP-1 release and independent of changes in insulin sensitivity, weight-loss and caloric restriction.
Original languageEnglish
JournalDiabetes Care
Volume33
Issue number2
Pages (from-to)375-7
ISSN0149-5992
DOIs
Publication statusPublished - 2010

ID: 32573422