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Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease

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Harvard

El-Hussuna, A, Karer, MLM, Uldall Nielsen, NN, Mujukian, A, Fleshner, PR, Iesalnieks, I, Horesh, N, Kopylov, U, Jacoby, H, Al-Qaisi, HM, Colombo, F, Sampietro, GM, Marino, MV, Ellebæk, M, Steenholdt, C, Sørensen, N, Celentano, V, Ladwa, N, Warusavitarne, J, Pellino, G, Zeb, A, Di Candido, F, Hurtado-Pardo, L, Frasson, M, Kunovsky, L, Yalcinkaya, A, Tatar, OC, Alonso, S, Pera, M, Granero, AG, Rodríguez, CA, Minaya, A, Spinelli, A & Qvist, N 2021, 'Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease', BJS open, vol. 5, no. 5, zrab075, pp. 1-9. https://doi.org/10.1093/bjsopen/zrab075

APA

El-Hussuna, A., Karer, M. L. M., Uldall Nielsen, N. N., Mujukian, A., Fleshner, P. R., Iesalnieks, I., Horesh, N., Kopylov, U., Jacoby, H., Al-Qaisi, H. M., Colombo, F., Sampietro, G. M., Marino, M. V., Ellebæk, M., Steenholdt, C., Sørensen, N., Celentano, V., Ladwa, N., Warusavitarne, J., ... Qvist, N. (2021). Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease. BJS open, 5(5), 1-9. [zrab075]. https://doi.org/10.1093/bjsopen/zrab075

CBE

El-Hussuna A, Karer MLM, Uldall Nielsen NN, Mujukian A, Fleshner PR, Iesalnieks I, Horesh N, Kopylov U, Jacoby H, Al-Qaisi HM, Colombo F, Sampietro GM, Marino MV, Ellebæk M, Steenholdt C, Sørensen N, Celentano V, Ladwa N, Warusavitarne J, Pellino G, Zeb A, Di Candido F, Hurtado-Pardo L, Frasson M, Kunovsky L, Yalcinkaya A, Tatar OC, Alonso S, Pera M, Granero AG, Rodríguez CA, Minaya A, Spinelli A, Qvist N. 2021. Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease. BJS open. 5(5):1-9. https://doi.org/10.1093/bjsopen/zrab075

MLA

Vancouver

Author

El-Hussuna, A ; Karer, M L M ; Uldall Nielsen, N N ; Mujukian, A ; Fleshner, P R ; Iesalnieks, I ; Horesh, N ; Kopylov, U ; Jacoby, H ; Al-Qaisi, H M ; Colombo, F ; Sampietro, G M ; Marino, M V ; Ellebæk, M ; Steenholdt, C ; Sørensen, N ; Celentano, V ; Ladwa, N ; Warusavitarne, J ; Pellino, G ; Zeb, A ; Di Candido, F ; Hurtado-Pardo, L ; Frasson, M ; Kunovsky, L ; Yalcinkaya, A ; Tatar, O C ; Alonso, S ; Pera, M ; Granero, A G ; Rodríguez, C A ; Minaya, A ; Spinelli, A ; Qvist, N. / Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease. In: BJS open. 2021 ; Vol. 5, No. 5. pp. 1-9.

Bibtex

@article{1a90742fda80496b8bce73669a11960e,
title = "Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease",
abstract = "BACKGROUND: In patients with active Crohn's disease (CD), treatment of intra-abdominal abscess usually comprises antibiotics and radiologically guided percutaneous drainage (PD) preceding surgery. The aim of this study was to investigate the risk of postoperative complications and identify the optimal time interval for surgical intervention after PD.METHODS: A multicentre, international, retrospective cohort study was carried out. Details of patients with diagnosis of CD who underwent ultrasonography- or CT-guided PD were retrieved from hospital records using international classification of disease (ICD-10) diagnosis code for CD combined with procedure code for PD. Clinical variables were retrieved and the following outcomes were measured: 30-day postoperative overall complications, intra-abdominal septic complications, unplanned intraoperative adverse events, surgical-site infections, sepsis and pathological postoperative ileus, in addition to abscess recurrence. Patients were categorized into three groups according to the length of the interval from PD to surgery (1-14 days, 15-30 days and more than 30 days) for comparison of outcomes.RESULTS: The cohort comprised 335 CD patients with PD followed by surgery. Median age was 33 (i.q.r. 24-44) years, 152 (45.4 per cent) were females, and median disease duration was 9 (i.q.r. 3.6-15) years. Overall, the 30-day postoperative complications rate was 32.2 per cent and the mortality rate was 1.5 per cent. After adjustment for co-variables, older age (odds ratio 1.03 (95 per cent c.i. 1.01 to 1.06), P < 0.012), residual abscess after PD (odds ratio 0.374 (95 per cent c.i. 0.19 to 0.74), P < 0.014), smoking (odds ratio 1.89 (95 per cent c.i. 1.01 to 3.53), P = 0.049) and low serum albumin concentration (odds ratio 0.921 (95 per cent c.i. 0.89 to 0.96), P < 0.001) were associated with higher rates of postoperative complications. A short waiting interval, less than 2 weeks after PD, was associated with a high incidence of abscess recurrence (odds ratio 0.59 (95 per cent c.i. 0.36 to 0.96), P = 0.042).CONCLUSION: Smoking, low serum albumin concentration and older age were significantly associated with postoperative complications. An interval of at least 2 weeks after successful PD correlated with reduced risk of abscess recurrence.",
author = "A El-Hussuna and Karer, {M L M} and {Uldall Nielsen}, {N N} and A Mujukian and Fleshner, {P R} and I Iesalnieks and N Horesh and U Kopylov and H Jacoby and Al-Qaisi, {H M} and F Colombo and Sampietro, {G M} and Marino, {M V} and M Elleb{\ae}k and C Steenholdt and N S{\o}rensen and V Celentano and N Ladwa and J Warusavitarne and G Pellino and A Zeb and {Di Candido}, F and L Hurtado-Pardo and M Frasson and L Kunovsky and A Yalcinkaya and Tatar, {O C} and S Alonso and M Pera and Granero, {A G} and Rodr{\'i}guez, {C A} and A Minaya and A Spinelli and N Qvist",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.",
year = "2021",
month = sep,
day = "6",
doi = "10.1093/bjsopen/zrab075",
language = "English",
volume = "5",
pages = "1--9",
journal = "BJS open",
issn = "2474-9842",
publisher = "John Wiley & Sons Ltd.",
number = "5",

}

RIS

TY - JOUR

T1 - Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease

AU - El-Hussuna, A

AU - Karer, M L M

AU - Uldall Nielsen, N N

AU - Mujukian, A

AU - Fleshner, P R

AU - Iesalnieks, I

AU - Horesh, N

AU - Kopylov, U

AU - Jacoby, H

AU - Al-Qaisi, H M

AU - Colombo, F

AU - Sampietro, G M

AU - Marino, M V

AU - Ellebæk, M

AU - Steenholdt, C

AU - Sørensen, N

AU - Celentano, V

AU - Ladwa, N

AU - Warusavitarne, J

AU - Pellino, G

AU - Zeb, A

AU - Di Candido, F

AU - Hurtado-Pardo, L

AU - Frasson, M

AU - Kunovsky, L

AU - Yalcinkaya, A

AU - Tatar, O C

AU - Alonso, S

AU - Pera, M

AU - Granero, A G

AU - Rodríguez, C A

AU - Minaya, A

AU - Spinelli, A

AU - Qvist, N

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of BJS Society Ltd.

PY - 2021/9/6

Y1 - 2021/9/6

N2 - BACKGROUND: In patients with active Crohn's disease (CD), treatment of intra-abdominal abscess usually comprises antibiotics and radiologically guided percutaneous drainage (PD) preceding surgery. The aim of this study was to investigate the risk of postoperative complications and identify the optimal time interval for surgical intervention after PD.METHODS: A multicentre, international, retrospective cohort study was carried out. Details of patients with diagnosis of CD who underwent ultrasonography- or CT-guided PD were retrieved from hospital records using international classification of disease (ICD-10) diagnosis code for CD combined with procedure code for PD. Clinical variables were retrieved and the following outcomes were measured: 30-day postoperative overall complications, intra-abdominal septic complications, unplanned intraoperative adverse events, surgical-site infections, sepsis and pathological postoperative ileus, in addition to abscess recurrence. Patients were categorized into three groups according to the length of the interval from PD to surgery (1-14 days, 15-30 days and more than 30 days) for comparison of outcomes.RESULTS: The cohort comprised 335 CD patients with PD followed by surgery. Median age was 33 (i.q.r. 24-44) years, 152 (45.4 per cent) were females, and median disease duration was 9 (i.q.r. 3.6-15) years. Overall, the 30-day postoperative complications rate was 32.2 per cent and the mortality rate was 1.5 per cent. After adjustment for co-variables, older age (odds ratio 1.03 (95 per cent c.i. 1.01 to 1.06), P < 0.012), residual abscess after PD (odds ratio 0.374 (95 per cent c.i. 0.19 to 0.74), P < 0.014), smoking (odds ratio 1.89 (95 per cent c.i. 1.01 to 3.53), P = 0.049) and low serum albumin concentration (odds ratio 0.921 (95 per cent c.i. 0.89 to 0.96), P < 0.001) were associated with higher rates of postoperative complications. A short waiting interval, less than 2 weeks after PD, was associated with a high incidence of abscess recurrence (odds ratio 0.59 (95 per cent c.i. 0.36 to 0.96), P = 0.042).CONCLUSION: Smoking, low serum albumin concentration and older age were significantly associated with postoperative complications. An interval of at least 2 weeks after successful PD correlated with reduced risk of abscess recurrence.

AB - BACKGROUND: In patients with active Crohn's disease (CD), treatment of intra-abdominal abscess usually comprises antibiotics and radiologically guided percutaneous drainage (PD) preceding surgery. The aim of this study was to investigate the risk of postoperative complications and identify the optimal time interval for surgical intervention after PD.METHODS: A multicentre, international, retrospective cohort study was carried out. Details of patients with diagnosis of CD who underwent ultrasonography- or CT-guided PD were retrieved from hospital records using international classification of disease (ICD-10) diagnosis code for CD combined with procedure code for PD. Clinical variables were retrieved and the following outcomes were measured: 30-day postoperative overall complications, intra-abdominal septic complications, unplanned intraoperative adverse events, surgical-site infections, sepsis and pathological postoperative ileus, in addition to abscess recurrence. Patients were categorized into three groups according to the length of the interval from PD to surgery (1-14 days, 15-30 days and more than 30 days) for comparison of outcomes.RESULTS: The cohort comprised 335 CD patients with PD followed by surgery. Median age was 33 (i.q.r. 24-44) years, 152 (45.4 per cent) were females, and median disease duration was 9 (i.q.r. 3.6-15) years. Overall, the 30-day postoperative complications rate was 32.2 per cent and the mortality rate was 1.5 per cent. After adjustment for co-variables, older age (odds ratio 1.03 (95 per cent c.i. 1.01 to 1.06), P < 0.012), residual abscess after PD (odds ratio 0.374 (95 per cent c.i. 0.19 to 0.74), P < 0.014), smoking (odds ratio 1.89 (95 per cent c.i. 1.01 to 3.53), P = 0.049) and low serum albumin concentration (odds ratio 0.921 (95 per cent c.i. 0.89 to 0.96), P < 0.001) were associated with higher rates of postoperative complications. A short waiting interval, less than 2 weeks after PD, was associated with a high incidence of abscess recurrence (odds ratio 0.59 (95 per cent c.i. 0.36 to 0.96), P = 0.042).CONCLUSION: Smoking, low serum albumin concentration and older age were significantly associated with postoperative complications. An interval of at least 2 weeks after successful PD correlated with reduced risk of abscess recurrence.

UR - http://www.scopus.com/inward/record.url?scp=85116278988&partnerID=8YFLogxK

U2 - 10.1093/bjsopen/zrab075

DO - 10.1093/bjsopen/zrab075

M3 - Journal article

C2 - 34518869

VL - 5

SP - 1

EP - 9

JO - BJS open

JF - BJS open

SN - 2474-9842

IS - 5

M1 - zrab075

ER -

ID: 67612382